衰老的分子机制。一篇评论。

Molecular mechanisms of ageing. A critique.

作者信息

Burch P R, Jackson D

出版信息

Gerontology. 1976;22(3):206-11. doi: 10.1159/000212135.

Abstract

Two kinds of evidence, taken in conjunction, indicate that Orgel's theory is inapplicable to a wide range of disorders of senescence in man. The age dependence and the anatomical distribution of the lesions of such disorders imply a Burnet type 'forbidden clone' theory of ageing. We describe the difficulty of establishing Orgel's theory for any disorder of ageing in man.

摘要

两种证据结合起来表明，奥格尔的理论不适用于人类广泛的衰老相关病症。此类病症损伤的年龄依赖性和解剖学分布意味着衰老的伯内特型“禁忌克隆”理论。我们阐述了在人类任何衰老病症中确立奥格尔理论的困难。