Steen R Grant, Schroeder Jason
Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, USA.
Magn Reson Imaging. 2003 Jan;21(1):9-15. doi: 10.1016/s0730-725x(02)00635-5.
The goal of this study was to characterize the expected range of variation in T1 (spin-lattice relaxation time) of brain tissue in vivo, as a function of age, and to use these maturational norms to study children with sickle cell disease (SCD). A well-validated method (TurboPAIR) was used to measure T1 in 10 tissues in a study group of 200 healthy subjects (ages 4.5 to 79.3; 101 male and 99 female), in a transverse slice at the level of the basal ganglia. Brain T1 was significantly related to age in every tissue characterized (p < 0.001), including the splenium (p < 0.01). Quantitative MRI suggests that brain T1 continues to change throughout the lifespan of healthy subjects free of neurologic complaints. Age-related changes follow a different schedule in each tissue, and age is a stronger determinant of T1 in gray matter than in white matter. Analysis of 141 patients with SCD shows that patients have lower T1 than normal, in both the caudate and the cortex (p < 0.001).
本研究的目的是确定活体脑组织T1（自旋晶格弛豫时间）随年龄变化的预期范围，并利用这些成熟标准来研究镰状细胞病（SCD）患儿。在一个由200名健康受试者（年龄4.5至79.3岁；101名男性和99名女性）组成的研究组中，采用一种经过充分验证的方法（TurboPAIR）在基底节水平的横断面上测量10个组织的T1。在所研究的每个组织中，脑T1与年龄均显著相关（p<0.001），包括胼胝体（p<0.01）。定量MRI表明，在无神经系统疾病的健康受试者的整个生命周期中，脑T1持续变化。各组织中与年龄相关的变化遵循不同的模式，年龄对灰质T1的决定作用比对白质更强。对141例SCD患者的分析表明，患者尾状核和皮质的T1均低于正常水平（p<0.001）。
