[Systemic changes in occupational vitiligo].

In three patients with occupational vitiligo caused by paratertiary butylphenol--the first cases observed in the BRD--a functional disorder of the liver was found. In two of these patients splenomegaly was seen. The laboratory findings, the laparoscopic examination and the result of the liver-biopsy are described. It is assumed that these changes as well as the depigmentation and a functional disorder of the thyroid (described elsewhere) are caused by the systemic action of inhaled paratertiary butylphenol.