Bodner Klaus, Bodner-Adler Barbara, Kimberger Oliver, Czerwenka Klaus, Leodolter Sepp, Mayerhofer Klaus
Departments of Gynecology and Obstetrics, Gynecopathology and of Anesthesiology, University of Vienna Medical School, A-1090 Vienna, Währinger Gürtel 18-20, Austria.
J Reprod Med. 2003 Feb;48(2):95-100.
To evaluate the prognostic impact of different clinicopathologic parameters in patients with uterine leiomyosarcoma.
Twenty-one patients with histologically proven uterine leiomyosarcoma were included in the analysis. Leiomyosarcomas were defined as uterine smooth muscle tumors with > or = 5 mitoses per 10 high-power fields and nuclear atypia and/or necrosis.
The median follow-up time was 47 months; 5-year overall survival was 41%. A univariate Cox model revealed that early tumor stage (P = .00001), age at diagnosis < 50 years (P = .02), absence of vascular space involvement (P = .04), low myometrial invasion (P = .006) and low histologic grade (P = .04) were associated with lengthened overall survival. Adjuvant radiotherapy and/or chemotherapy (P = .1) did not influence overall survival.
Early tumor stage, age at diagnosis < 50 years, absence of vascular space invasion, low myometrial invasion and low histologic grade were parameters of a good prognosis in women with uterine leiomyosarcoma. Adjuvant chemotherapy and/or radiotherapy showed no benefit in these patients.
评估不同临床病理参数对子宫平滑肌肉瘤患者预后的影响。
分析纳入21例经组织学证实的子宫平滑肌肉瘤患者。平滑肌肉瘤定义为每10个高倍视野有≥5个核分裂象且伴有核异型性和/或坏死的子宫平滑肌肿瘤。
中位随访时间为47个月；5年总生存率为41%。单因素Cox模型显示，肿瘤早期（P = .00001）、诊断时年龄<50岁（P = .02）、无脉管间隙受累（P = .04）、肌层浸润程度低（P = .006）和组织学分级低（P = .04）与总生存时间延长相关。辅助放疗和/或化疗（P = .1）对总生存无影响。
肿瘤早期、诊断时年龄<50岁、无脉管间隙浸润、肌层浸润程度低和组织学分级低是子宫平滑肌肉瘤患者预后良好的参数。辅助化疗和/或放疗对这些患者无益处。
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