28 例子宫平滑肌肉瘤的预后因素和结果。

Prognostic factors and outcomes in 28 cases of uterine leiomyosarcoma.

机构信息

Department of Gynecology, Obstetrics and Neonatology, University of Bari, Bari, Italy.

出版信息

Oncology. 2011;81(2):91-7. doi: 10.1159/000331679. Epub 2011 Oct 3.

DOI:10.1159/000331679

PMID:21968290

Abstract

OBJECTIVES

It was the aim of this study to evaluate clinicopathological characteristics and prognostic factors of uterine leiomyosarcomas (LMS).

METHODS

Twenty-eight patients with uterine LMS were evaluated in this retrospective study. Their features and survival were analyzed by Kaplan-Meier and log-rank tests.

RESULTS

The median age of the patients was 52 years (range 25-74). Nine patients had a disease with a mitotic count <10/10 high-power fields. Twenty-one patients presented with stage I disease, 1 with stage II and 6 with stage IV. Twelve patients underwent total hysterectomy and bilateral salpingo-oophorectomy, 2 simple hysterectomy, 5 myomectomy and 9 more comprehensive surgical treatments. Adjuvant chemotherapy was administered to 16 patients, whereas chemoradiation was given only to 2 patients. Fifty percent presented with recurrence of the disease. The median overall survival was 46 months. Age, mitotic count, type of surgery, adjuvant therapy, recurrence and clinical response to chemotherapy were not found to affect survival, while the menopausal status and FIGO (International Federation of Gynecology and Obstetrics) stage were found to be prognostic factors.

CONCLUSION

In our series, the menopausal state and FIGO stage were found to be prognostic factors related to survival.

摘要

目的

本研究旨在评估子宫平滑肌肉瘤（LMS）的临床病理特征和预后因素。

方法

在这项回顾性研究中评估了 28 例患有子宫 LMS 的患者。通过 Kaplan-Meier 和对数秩检验分析他们的特征和生存情况。

结果

患者的中位年龄为 52 岁（范围 25-74 岁）。9 名患者的有丝分裂计数<10/10 高倍视野。21 名患者为 I 期疾病，1 名患者为 II 期，6 名患者为 IV 期。12 名患者接受了全子宫切除术和双侧输卵管卵巢切除术，2 名患者接受了单纯子宫切除术，5 名患者接受了子宫肌瘤切除术，9 名患者接受了更全面的手术治疗。16 名患者接受了辅助化疗，而只有 2 名患者接受了放化疗。50%的患者出现疾病复发。中位总生存期为 46 个月。年龄、有丝分裂计数、手术类型、辅助治疗、复发和对化疗的临床反应均未发现影响生存，而绝经状态和 FIGO（国际妇产科联合会）分期被发现是预后因素。