Visser L G, Groen J
Leids Universitair Medisch Centrum, afd. Infectieziekten, Postbus 9600, 2300 RC Leiden.
Ned Tijdschr Geneeskd. 2003 Feb 8;147(6):254-7.
A 58-year-old entomologist presented with disabling arthralgia after a recent visit to the Northern Territory of Australia. A faint maculopapular rash was noticed on the trunk and limbs. The presumptive diagnosis of RRV disease was confirmed by the finding of IgM and IgG antibodies against RRV in serum. RRV, a mosquito-transmitted alpha virus, is the most common cause of arboviral disease in Australia. This disease, initially referred to as epidemic polyarthritis, is characterised by joint pain, rash and constitutional manifestations. The reservoir of RRV are marsupials, other mammals and birds, but mosquitoes may also transmit the disease between humans. The diagnosis is mainly based on RRV-specific serology. In case of arthritis viral RNA sometimes can be detected in synovium biopsies by PCR. No specific therapy is available; the prognosis is favourable. Prevention is based on protection against mosquito bites by wearing clothes to protect the skin, and by using insect repellents.
一名58岁的昆虫学家在近期访问澳大利亚北领地后出现了致残性关节痛。在其躯干和四肢发现了淡红色斑丘疹。血清中检测到抗RRV的IgM和IgG抗体,从而确诊为RRV病。RRV是一种由蚊子传播的甲病毒,是澳大利亚虫媒病毒病最常见的病因。这种疾病最初被称为流行性多关节炎,其特征为关节疼痛、皮疹和全身症状。RRV的宿主为有袋动物、其他哺乳动物和鸟类,但蚊子也可在人与人之间传播该病。诊断主要基于RRV特异性血清学检查。对于关节炎患者,有时可通过PCR在滑膜活检中检测到病毒RNA。目前尚无特效治疗方法;预后良好。预防措施包括穿防护服保护皮肤以及使用驱虫剂以防蚊虫叮咬。