Hassan S S M, Mahmoud W H, Elmosallamy M A F, Almarzooqi M H
Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
Pharmazie. 2003 Jan;58(1):29-31.
A novel potentiometric PVC membrane sensor for determination of diclofenac in pharmaceutical preparations has been developed. The sensor is based on the use of the 2,4,6-tri(2-pyridyl)-s-triazine iron(II) diclofenac complex [diclofenac-TPTZ-Fe(II)] as an electroactive material in a plasticized PVC membrane matrix. The sensor exhibits fast, stable and near Nernstian response for diclofenac over the concentration range 10(-2)-10(-6) M and pH 5.5-9.5. Application to quality control analysis of diclofenac in various dosage forms shows an average recovery of 99% with a mean standard deviation of 0.2%. No significant interferences are caused by inorganic and organic anions and various drug excipients and diluents.
已开发出一种用于测定药物制剂中双氯芬酸的新型电位型聚氯乙烯（PVC）膜传感器。该传感器基于将2,4,6-三（2-吡啶基）-s-三嗪铁（II）双氯芬酸配合物[双氯芬酸-TPTZ-Fe（II）]用作增塑PVC膜基质中的电活性材料。该传感器在10（-2）-10（-6）M的浓度范围和pH 5.5-9.5条件下，对双氯芬酸表现出快速、稳定且接近能斯特响应。将其应用于各种剂型中双氯芬酸的质量控制分析，平均回收率为99%，平均标准偏差为0.2%。无机和有机阴离子以及各种药物辅料和稀释剂均未产生明显干扰。
