氨甲酰霉酚酸乙酯，一种口服抗肿瘤药物。

Carbamoyl mycophenolic acid ethylester, an oral antitumor agent.

作者信息

Suzuki S, Mori T

出版信息

J Antibiot (Tokyo). 1976 Mar;29(3):286-91. doi: 10.7164/antibiotics.29.286.

DOI:10.7164/antibiotics.29.286

Abstract

Several derivatives of mycophenolic acid (MA) were tested for their antitumor activity against leukemia L-1210 when administered orally and carbamoyl mycophenolic acid ethylester (CMAE) was selected as the most active antitumor agent in these tests. An oral administration of CMAE also inhibited the growth of Ehrlich solid carcinoma, NF sarcoma, myeloma X-5563 and sarcoma 180 in mice. In comparison with antitumor activity of MA, the improvement in activity of CMAE against leukemia L-1210 and Ehrlich solid carcinoma was indeed remarkable, CMAE seems to be less immunosuppressive than MA.

摘要

对几种霉酚酸（MA）衍生物进行了口服给药时对白血病L-1210的抗肿瘤活性测试，在这些测试中，氨甲酰霉酚酸乙酯（CMAE）被选为活性最强的抗肿瘤剂。口服CMAE也能抑制小鼠艾氏实体癌、NF肉瘤、骨髓瘤X-5563和肉瘤180的生长。与MA的抗肿瘤活性相比，CMAE对白血病L-1210和艾氏实体癌的活性改善确实显著，CMAE的免疫抑制作用似乎比MA小。