组氨酸对粗糙脉孢菌嘌呤核苷酸合成及利用的影响。
Effect of histidine on purine nucleotide synthesis and utilization in Neurospora crassa.
作者信息
Pendyala L, Wellman A M
出版信息
J Bacteriol. 1975 Oct;124(1):78-85. doi: 10.1128/jb.124.1.78-85.1975.
Abstract
Histidine affects de novo purine nucleotide synthesis and purine nucleotide pool utilization in Neurospora crassa. The former effect was assessed qualitatively by the presence or absence of purple pigment production in ad3B and ad3A mutants. Tryptophan also affected the de novo purine nucleotide synthesis. The effect of histidine on purine nucleotide pool utilization resulted in stimulated germination of ad8 and ad4 mutant conidia in adenine-deficient medium. Increased germination was correlated with increased net levels of nucleic acids in these strains. Possible mechanisms for the dual action of histidine are discussed.
摘要
组氨酸影响粗糙脉孢菌中嘌呤核苷酸的从头合成及嘌呤核苷酸库的利用。通过ad3B和ad3A突变体中紫色色素产生的有无对前一种效应进行了定性评估。色氨酸也影响嘌呤核苷酸的从头合成。组氨酸对嘌呤核苷酸库利用的影响导致ad8和ad4突变体分生孢子在腺嘌呤缺乏的培养基中萌发受到刺激。萌发增加与这些菌株中核酸净水平的增加相关。讨论了组氨酸双重作用的可能机制。
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