2型糖尿病相关弥漫性特发性骨肥厚绝经后女性的轴向骨密度研究
Study of axial bone mineral density in postmenopausal women with diffuse idiopathic skeletal hyperostosis related to type 2 diabetes mellitus.
作者信息
Sahin Günsah, Polat Gürbüz, Bagis Selda, Milcan Abtullah, Erdogan Canan
机构信息
Mersin University, Faculty of Medicine, Department of PMR, Mersin, Turkey.
出版信息
J Womens Health (Larchmt). 2002 Nov;11(9):801-4. doi: 10.1089/15409990260430945.
OBJECTIVE
The association of bone mineral density (BMD) with diffuse idiopathic skeletal hyperostosis (DISH) related to diabetes mellitus was studied.
METHODS
We measured BMD and elevated known determinants of BMD (bone markers) in 35 patients with DISH-related type 2 diabetes mellitus, 47 type 2 female diabetics, and 52 female controls with no systemic disease and no drug administration. All subjects were matched for age and body mass index (BMI). All subjects were in the postmenopausal period.
RESULTS
Among subjects, BMD values were significantly higher in DISH patients than in diabetics and controls (p < 0.05). In addition, the duration of diabetes mellitus was longer in DISH patients and significantly correlated with total hip BMD in DISH patients (p < 0.05).
CONCLUSIONS
Patients with DISH have higher BMD, and increased BMD probably results from hyperostosis of the axial skeleton, which may cause decreased fracture risk.
目的
研究骨密度（BMD）与糖尿病相关的弥漫性特发性骨肥厚（DISH）之间的关联。
方法
我们测量了35例DISH相关2型糖尿病患者、47例2型女性糖尿病患者以及52例无全身性疾病且未服药的女性对照者的骨密度，并检测了已知的骨密度决定因素（骨标志物）。所有受试者均根据年龄和体重指数（BMI）进行匹配。所有受试者均处于绝经后时期。
结果
在受试者中，DISH患者的骨密度值显著高于糖尿病患者和对照者（p < 0.05）。此外，DISH患者的糖尿病病程更长，且与DISH患者的全髋骨密度显著相关（p < 0.05）。
结论
DISH患者具有更高的骨密度，骨密度增加可能是由于中轴骨骼的骨质增生所致，这可能会降低骨折风险。
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