McLaren A T, Allen J, Murray A, Ballard C G, Kenny R A
Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
Dement Geriatr Cogn Disord. 2003;15(4):183-8. doi: 10.1159/000068781.
Heart rate variability is used to assess cardiovascular autonomic function. The cholinesterase inhibitor donepezil potentially affects parasympathetic activity. Twenty participants with Alzheimer's disease or dementia with Lewy bodies were treated with donepezil in a pilot study. Power spectral analysis was used to analyse 5 min of beat-to-beat RR interval data in 15 cases. Heart rate variability was significantly reduced following treatment with donepezil; mainly for high frequency (median changed from 581 to 78 ms2; p = 0.001) but also for total power (median changed from 1,563 to 844 ms2; p = 0.047). Donepezil may adversely influence cardiovascular autonomic control. These results indicate the need for larger controlled trials to further investigate the cardiovascular effects of donepezil.
心率变异性用于评估心血管自主神经功能。胆碱酯酶抑制剂多奈哌齐可能会影响副交感神经活动。在一项初步研究中，20名患有阿尔茨海默病或路易体痴呆的参与者接受了多奈哌齐治疗。对15例患者5分钟逐搏RR间期数据进行功率谱分析。多奈哌齐治疗后心率变异性显著降低；主要是高频部分（中位数从581变为78 ms2；p = 0.001），总功率也降低（中位数从1563变为844 ms2；p = 0.047）。多奈哌齐可能会对心血管自主神经控制产生不利影响。这些结果表明需要进行更大规模的对照试验，以进一步研究多奈哌齐对心血管的影响。
