Ané Cécile, Concordet Didier
UMR 181, Physiopathologie et Toxicologie Expérimentales, Ecole Vétérinaire de Toulouse, 23 chemin des Capelles, 31076 Toulouse Cedex, France.
Stat Med. 2003 Mar 30;22(6):833-46. doi: 10.1002/sim.1448.
This paper proposes a method for studying the toxicity of an anticancer drug with a delayed effect. The goal is to predict a dosage regimen with controlled toxicity. To this end, a semi-physiological model is used. A limit of toxicity is demonstrated, which is intrinsic to the model. It reduces the effect of high drug concentrations. This limit explains the mixed behaviour of the drug: time-dependence and concentration-dependence, according to the dose actually administered. A population analysis is performed to estimate the parameters of the model, and to predict a safe dosage regimen.
本文提出了一种研究具有延迟效应的抗癌药物毒性的方法。目标是预测具有可控毒性的给药方案。为此，使用了一个半生理模型。证明了存在一个毒性极限，这是该模型所固有的。它降低了高药物浓度的影响。根据实际给药剂量，这个极限解释了药物的混合行为：时间依赖性和浓度依赖性。进行群体分析以估计模型参数，并预测安全的给药方案。
