Marquez Javier, Flores Diana, Candia Liliana, Espinoza Luis R
Section of Rheumatology, Department of Medicine, Louisiana State University, New Orleans 70112, USA.
Curr Rheumatol Rep. 2003 Apr;5(2):128-35. doi: 10.1007/s11926-003-0040-6.
Granulomatous vasculitis is a subset of systemic necrotizing vasculitis and has granulomatous inflammation as the main histopathologic feature. Etiopathogenesis remains poorly understood, although recent advances suggest an important role for certain pro-inflammatory cytokines, such as tumor necrosis factor-alpha. They are a heterogeneous group of clinical disorders with protean manifestations. Serologic abnormalities are present, and the presence of granular cytoplasmic staining-antineutrophil cytoplasmic antibodies is most important and is particularly useful for the diagnosis of active Wegener's granulomatosis. Corticosteroids and cyclophosphamide remain very useful in the treatment of most of these disorders.
肉芽肿性血管炎是系统性坏死性血管炎的一个子集，以肉芽肿性炎症为主要组织病理学特征。尽管最近的研究进展表明某些促炎细胞因子（如肿瘤坏死因子-α）起重要作用，但病因发病机制仍了解甚少。它们是一组临床表现多样的异质性临床疾病。存在血清学异常，其中颗粒状细胞质染色抗中性粒细胞胞浆抗体的存在最为重要，对活动性韦格纳肉芽肿的诊断尤为有用。皮质类固醇和环磷酰胺在治疗大多数此类疾病中仍然非常有效。
