Malatesta Paolo, Hack Michael A, Hartfuss Eva, Kettenmann Helmut, Klinkert Wolfgang, Kirchhoff Frank, Götz Magdalena
Max-Planck Institute of Neurobiology, Am Klopferspitz 18A, D-82152 Planegg-Martinsried, Germany.
Neuron. 2003 Mar 6;37(5):751-64. doi: 10.1016/s0896-6273(03)00116-8.
The precursor function of the ubiquitous glial cell type in the developing central nervous system (CNS), the radial glia, is largely unknown. Using Cre/loxP in vivo fate mapping studies, we found that radial glia generate virtually all cortical projection neurons but not the interneurons originating in the ventral telencephalon. In contrast to the cerebral cortex, few neurons in the basal ganglia originate from radial glia, and in vitro lineage analysis revealed intrinsic differences in the potential of radial glia from the dorsal and ventral telencephalon. This shows that the progeny of radial glia not only differs profoundly between brain regions but also includes the majority of neurons in some parts of the CNS.
在发育中的中枢神经系统（CNS）中普遍存在的神经胶质细胞类型——放射状胶质细胞的前体功能，在很大程度上尚不清楚。利用Cre/loxP体内命运图谱研究，我们发现放射状胶质细胞几乎产生了所有的皮质投射神经元，但不产生起源于腹侧端脑的中间神经元。与大脑皮质不同，基底神经节中很少有神经元起源于放射状胶质细胞，并且体外谱系分析揭示了背侧和腹侧端脑放射状胶质细胞在潜能上的内在差异。这表明放射状胶质细胞的后代不仅在脑区之间存在深刻差异，而且在中枢神经系统某些部位还包括了大多数神经元。
