Wanzel Michael, Herold Steffi, Eilers Martin
Institute for Molecular Biology and Tumour Research (IMT), University of Marburg, Marburg 35033, Germany.
Trends Cell Biol. 2003 Mar;13(3):146-50. doi: 10.1016/s0962-8924(03)00003-5.
The Myc oncoprotein is a transcription factor that can both activate and repress genes. Transcriptional activation by Myc is well understood, but, by contrast, the mechanisms through which Myc represses transcription have remained elusive. Recent evidence suggests that complex formation by Myc with a zinc-finger transcription factor, Miz-1, plays an important role in mediating repression by Myc. The findings might explain how Myc interferes with cell-cycle arrest in response to TGF-beta, APC and DNA damage.
Myc癌蛋白是一种既能激活基因又能抑制基因的转录因子。Myc介导的转录激活作用已得到充分了解，然而，相比之下，Myc抑制转录的机制仍不清楚。最近的证据表明，Myc与锌指转录因子Miz-1形成复合物在介导Myc的抑制作用中发挥重要作用。这些发现或许可以解释Myc如何干扰细胞对转化生长因子-β、腺瘤性结肠息肉病蛋白和DNA损伤作出的细胞周期停滞反应。
