Picchio M, Messa C, Landoni C, Gianolli L, Sironi S, Brioschi M, Matarrese M, Matei D V, De Cobelli F, Del Maschio A, Rocco F, Rigatti P, Fazio F
Institute H. San Raffaele, University of Milano-Bicocca, Italy.
J Urol. 2003 Apr;169(4):1337-40. doi: 10.1097/01.ju.0000056901.95996.43.
We compared [11C]choline-positron emission tomography (PET) with [18F]fluorodeoxyglucose-PET for re-staging prostate cancer in a group of 100 patients.
A total of 100 consecutive patients referred for whole body [18F]fluorodeoxyglucose-PET for clinical prostate re-staging after radical treatment for prostate cancer were retrospectively included in the study. Mean prostate specific antigen (PSA) was 6.57 ng./ml. In all cases [11C]choline-PET was also performed. PET studies were done with a multiring device 5 minutes after intravenous injection of approximately 370 MBq. [11C]choline and 60 minutes after injection of approximately 370 MBq. [18F]fluorodeoxyglucose. PET findings were compared with those obtained with different conventional imaging and with PSA assessed at the time of PET and 1 year later.
Areas of abnormal focal increases were noted in 47% of patients on [11C]choline-PET and in 27% on [18F]fluorodeoxyglucose-PET. Of the 100 patients 49 had positive conventional imaging findings. All except 14 [11C]choline-PET findings were concordant with conventional imaging, including 6 negative and 8 positive conventional imaging results. All except 1 [11C]choline-PET negative cases also had negative conventional imaging after 1 year. PSA at 1 year remained stable or decreased in 80% and 62% of [11C]choline-PET negative and positive cases, respectively.
[11C]choline-PET seems to be useful for re-staging prostatectomy cases with increasing serum PSA levels. It is superior to [18F]fluorodeoxyglucose-PET and complementary to conventional imaging but with the advantage of staging disease at a single step.
我们在一组100例患者中比较了[11C]胆碱正电子发射断层扫描（PET）与[18F]氟脱氧葡萄糖PET用于前列腺癌再分期的情况。
本研究回顾性纳入了100例因前列腺癌根治性治疗后进行临床前列腺再分期而接受全身[18F]氟脱氧葡萄糖PET检查的连续患者。平均前列腺特异性抗原（PSA）为6.57 ng/ml。所有病例均进行了[11C]胆碱PET检查。静脉注射约370 MBq [11C]胆碱后5分钟，以及注射约370 MBq [18F]氟脱氧葡萄糖后60分钟，使用多环设备进行PET检查。将PET检查结果与通过不同传统成像方法获得的结果以及PET检查时和1年后评估的PSA进行比较。
[11C]胆碱PET检查发现47%的患者存在异常局灶性增高区域，[18F]氟脱氧葡萄糖PET检查发现27%的患者存在异常局灶性增高区域。100例患者中，49例传统成像检查结果为阳性。除14例[11C]胆碱PET检查结果外，所有结果均与传统成像结果一致，包括6例传统成像检查结果为阴性和8例为阳性。除1例[11C]胆碱PET检查结果为阴性的病例外，其余所有病例1年后传统成像检查结果也为阴性。[11C]胆碱PET检查结果为阴性和阳性的病例中，1年后PSA保持稳定或下降的比例分别为80%和62%。
[11C]胆碱PET似乎有助于对血清PSA水平升高的前列腺切除病例进行再分期。它优于[18F]氟脱氧葡萄糖PET，是传统成像的补充，但具有一步完成疾病分期的优势。
