Oswald Josef, Brenner Erich, Deibl Martina, Fritsch Helga, Bartsch Georg, Radmayr Christian
Department of Urology, University of Innsbruck, Austria.
J Urol. 2003 Apr;169(4):1501-4. doi: 10.1097/01.ju.0000057047.82984.7f.
We define reference data concerning the development of the ureterovesical junction in fetuses and newborns by measuring the diameters of the distal mesenchymal and muscular ureteral walls as well as intravesical ureteral length.
A total of 90 normal fetal and newborn ureters were investigated. Our histological studies were based on "plastinated" sections of whole pelves which allow study of the sectional anatomy of the distal and intravesical ureter. The development of the mesenchymal and smooth muscle growth of the distal and intravesical ureter was examined. The ureteral measurements were correlated with age of gestation.
The length of the intravesical ureter and mesenchymal as well as smooth muscle walls increased in a linear mode. Significant correlations (p <0.0001) were found between gestational age and the growth of the mesenchymal as well as smooth muscle walls in the distal intravesical ureter as well as the length of the intravesical ureter.
Significant positive linear relationships exist between gestational week, and distal and intravesical ureteral wall thickness of the mesenchymal and smooth muscle growth to the length of the intravesical ureter in fetuses and newborns. The ratio of the intravesical ureteral length-to-ureteral diameter is obviously lower than assumed previously. Data from this study can be used for a more accurate assessment of cases with abnormal lower urinary tract development.
通过测量远端间充质和肌肉输尿管壁的直径以及膀胱内输尿管长度，确定胎儿和新生儿输尿管膀胱连接处发育的参考数据。
共研究了90条正常胎儿和新生儿输尿管。我们的组织学研究基于整个骨盆的“塑化”切片，这有助于研究远端和膀胱内输尿管的断层解剖结构。检查了远端和膀胱内输尿管间充质和平滑肌生长的发育情况。输尿管测量值与妊娠年龄相关。
膀胱内输尿管的长度以及间充质和平滑肌壁呈线性增加。在胎龄与膀胱内远端输尿管间充质和平滑肌壁的生长以及膀胱内输尿管的长度之间发现了显著相关性（p<0.0001）。
在胎儿和新生儿中，孕周与远端和膀胱内输尿管壁间充质和平滑肌生长的厚度以及膀胱内输尿管的长度之间存在显著的正线性关系。膀胱内输尿管长度与输尿管直径的比值明显低于先前的假设。本研究的数据可用于更准确地评估下尿路发育异常的病例。
