Busse Tom
Department of Pharmacy, Gottlieb Memorial Hospital, Melrose Park, IL.
Clin J Oncol Nurs. 2003 Jan-Feb;7(1):104-5. doi: 10.1188/03.CJON.104-108.
Using AUC-based dosing compensates for variations in renal function between and within individual patients. It does not adjust for other factors such as previous chemotherapy, previous radiotherapy, or performance status. One empiric method to adjust for these factors would be reduction of the ideal AUC. However, because AUC-based dosing accounts for variations in renal function, this would not be an appropriate method to adjust dosing based solely on renal function changes.
基于曲线下面积（AUC）给药可补偿个体患者之间及个体患者内部肾功能的差异。它并未针对其他因素进行调整，如既往化疗、既往放疗或体能状态。针对这些因素进行调整的一种经验性方法是降低理想的AUC。然而，由于基于AUC给药考虑了肾功能的差异，这并非仅基于肾功能变化来调整给药的合适方法。
