基于1-四氢萘酮和1-茚满酮的单季铵神经肌肉阻滞剂。
Monoquaternary neuromuscular blocking agents based on 1-tetralone and 1-indanone.
作者信息
Biggs D F, Casy A F, Chu I, Coutts R T
出版信息
J Med Chem. 1976 Apr;19(4):472-5. doi: 10.1021/jm00226a004.
PMID:1263199
Abstract
The preparation of three isomeric 1-tetralone hydrozones 4 and three isomeric 1-indanone hydrozones 5 possessing a single quaternary ammonium center is described. Several of the compounds possessed significant neuromuscular blocking activity, and two approached suxamethonium in potency. 1H NMR evidence obtained from a study of the N,N-dimethylhydrozones indicated that the hydrazones adopted an E configuration in solution.
摘要
本文描述了三种具有单一季铵中心的异构1-四氢萘酮腙4和三种异构1-茚满酮腙5的制备方法。其中几种化合物具有显著的神经肌肉阻断活性，有两种的效力接近琥珀胆碱。对N,N-二甲基腙的研究获得的¹H NMR证据表明，这些腙在溶液中采取E构型。
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