Spengler M I, Goñi G M, Mengarelli G, Bravo Luna M, Bocanera R, Tozzini R, Rasia M L
Departamento de Ciencias Fisiológicas, Biofísica, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, CP 2000, Rosario, Argentina.
Clin Hemorheol Microcirc. 2003;28(1):13-9.
It is already admitted that hormone replacement therapy (HRT) decreases the risk of developing cardiovascular disease, although its mechanism is not clear yet. In the present work, the effect of the HRT upon cellular and plasmatic haemorheological factors determining blood flow properties: blood viscosity, plasma viscosity, plasma fibrinogen, rigidity erythrocyte index and erythrocyte aggregation rate was studied. Menopausal women were followed through a whole year of HTR. Results demonstrate that after six months of treatment there is a diminution in relative blood viscosity and erythrocyte rigidity, with constant values along the second semester. Erythrocyte aggregation, plasmatic and blood viscosity diminution observed during the treatment can be explained by the simultaneous plasma fibrinogen decrease. Modified cellular and plasmatic rheology could produce beneficial effects on blood flow, particularly in microcirculation, presenting a possible mechanism by which HTR decreases the risk of cardiovascular disease development during menopause.
尽管激素替代疗法（HRT）的作用机制尚不清楚，但人们已经公认它能降低患心血管疾病的风险。在本研究中，我们研究了HRT对决定血流特性的细胞和血浆血液流变学因素的影响：血液粘度、血浆粘度、血浆纤维蛋白原、红细胞刚性指数和红细胞聚集率。对绝经后妇女进行了一整年的HRT跟踪研究。结果表明，治疗六个月后，相对血液粘度和红细胞刚性降低，在第二学期保持恒定值。治疗期间观察到的红细胞聚集、血浆和血液粘度降低可以用血浆纤维蛋白原同时降低来解释。细胞和血浆流变学的改变可能对血流产生有益影响，特别是在微循环中，这可能是HRT降低绝经期间心血管疾病发生风险的一种机制。
