Ajmani Ranjeet S, Fleg Jerome L, Demehin A Andrew, Wright Jeanette G, O'Connor Frances, Heim Jane M, Tarien Edward, Rifkind Joseph M
National Institute on Aging, National Institutes of Health, Molecular Dynamics Section and the Laboratory of Cardiovascular Sciences, Baltimore, MD 21224, USA.
Clin Hemorheol Microcirc. 2003;28(1):29-40.
The present investigation was designed to evaluate the acute effect of aerobic exercise on oxidative stress and the flow properties of the blood. Fourteen clinically healthy subjects (7 men and 7 women aged 56+/-19 yr) underwent maximal treadmill exercise with blood samples drawn prior to and immediately after exercise. Post-exercise significant increases were observed in plasma lipid hydroperoxides from 6.5+/-2.0 microM to 7.9+/-1.9 microM (p<0.0001) and the relative concentration of plasma fluorescent products associated with red cell peroxidation from 138+/-28 RF to 220+/-92 RF (p<0.005). After exercise there was a rise in the hematocrit from 41.4+/-3.7% to 44.4+/-4.1% (p<0.0001), increases in whole blood viscosity at shear rates of 22.5/sec to 450/sec (p<0.0005), an increase in plasma viscosity from 1.27+/-0.12 cP to 1.36+/-0.11 cP (p<0.01), an increase in red cell rigidity from 2.44+/-0.48 cP to 2.62+/-0.42 cP (p<0.001) and a decrease in erythrocyte sedimentation rate from 26.9+/-18.6 mm/h to 22.5+/-15.9 mm/h (p<0.01). The findings suggest that acute aerobic exercise induces oxidative damage to red blood cells and adversely affects rheological properties of the peripheral blood.
本研究旨在评估有氧运动对氧化应激和血液流动特性的急性影响。14名临床健康受试者（7名男性和7名女性，年龄56±19岁）进行了最大强度的跑步机运动，在运动前和运动后立即采集血样。运动后，血浆脂质氢过氧化物从6.5±2.0微摩尔/升显著增加至7.9±1.9微摩尔/升（p<0.0001），与红细胞过氧化相关的血浆荧光产物相对浓度从138±28 RF增加至220±92 RF（p<0.005）。运动后，血细胞比容从41.4±3.7%升至44.4±4.1%（p<0.0001），全血在剪切速率为22.5/秒至450/秒时的粘度增加（p<0.0005），血浆粘度从1.27±0.12厘泊增加至1.36±0.11厘泊（p<0.01），红细胞刚性从2.44±0.48厘泊增加至2.62±0.42厘泊（p<0.001），红细胞沉降率从26.9±18.6毫米/小时降至22.5±15.9毫米/小时（p<0.01）。这些发现表明，急性有氧运动可诱导红细胞氧化损伤，并对外周血的流变学特性产生不利影响。
