Chung T W, Yu J J, Liu D Z
Department of Biomedical Engineering, Chung-Yuan Christian University, Chung-Li, Taiwan, China.
Diabet Med. 1998 May;15(5):380-5. doi: 10.1002/(SICI)1096-9136(199805)15:5<380::AID-DIA592>3.0.CO;2-8.
The effects of alpha-tocopherol nicotinate on blood viscoelasticity and viscosity and on lipid peroxidation stress in erythrocyte membranes in patients with Type 2 DM were investigated. Thirteen Type 2 diabetic subjects with retinopathy were given alpha-tocopherol nicotinate 300 mg tds, after meals, for 3 months. The treatment resulted in significant reductions of blood viscosity at different shear rates (e.g. -2.23 +/- 2.82 p<0.015, gamma = 1.5 s(-1)) and viscoelasticity (p<0.004); resistance of erythrocyte deformation (p<0.001) and lipid peroxidation stress in red cell membrane (malondialdehyde or MDA reduced by 0.17 +/- 0.13 nmol l(-1) p<0.005). Plasma viscosity, red cell rigidity, and HbA1c were unchanged. There were negative linear correlations between the indices of red cell deformability and the levels of MDA of red cell membrane both pre- and post-treatment (e.g. R = -0.79, p<0.001; R = -0.78, p<0.002, n = 13; pre- and post-, respectively). We suggest that the improvements of rheological properties of blood and red cell deformability by alpha-tocopherol nicotinate are mainly attributed to reducing lipid peroxidation stress on membrane of red blood cells. The treatment may be useful in slowing deterioration of microangiopathy in Type 2 DM.
研究了α-生育酚烟酸酯对2型糖尿病患者血液黏弹性、黏度以及红细胞膜脂质过氧化应激的影响。13例患有视网膜病变的2型糖尿病受试者，餐后口服α-生育酚烟酸酯300mg，每日3次，共3个月。治疗后不同剪切率下的血液黏度显著降低（例如，-2.23±2.82，p<0.015，γ = 1.5 s(-1)），黏弹性也显著降低（p<0.004）；红细胞变形阻力（p<0.001）以及红细胞膜脂质过氧化应激（丙二醛或MDA降低0.17±0.13 nmol l(-1)，p<0.005）。血浆黏度、红细胞刚性和糖化血红蛋白A1c未发生变化。治疗前后红细胞变形性指标与红细胞膜MDA水平均呈负线性相关（例如，R = -0.79，p<0.001；R = -0.78，p<0.002，n = 13；分别为治疗前和治疗后）。我们认为，α-生育酚烟酸酯对血液流变学特性和红细胞变形性的改善主要归因于减轻红细胞膜的脂质过氧化应激。该治疗可能有助于延缓2型糖尿病微血管病变的恶化。
