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本文引用的文献

1
Natriuretic peptide system gene expression in human coronary arteries.利钠肽系统基因在人冠状动脉中的表达。
J Histochem Cytochem. 2002 Jun;50(6):799-809. doi: 10.1177/002215540205000606.
2
Natriuretic peptide receptor-B in adult rat ventricle is predominantly confined to the nonmyocyte population.
Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2117-23. doi: 10.1152/ajpheart.00988.2001.
3
Accelerated reendothelialization with suppressed thrombogenic property and neointimal hyperplasia of rabbit jugular vein grafts by adenovirus-mediated gene transfer of C-type natriuretic peptide.通过腺病毒介导的C型利钠肽基因转移促进兔颈静脉移植物的再内皮化，同时抑制其血栓形成特性和内膜增生。
Circulation. 2002 Apr 9;105(14):1623-6. doi: 10.1161/01.cir.0000014985.50017.6e.
4
Expression and control of C-type natriuretic peptide in rat vascular smooth muscle cells.大鼠血管平滑肌细胞中C型利钠肽的表达与调控
Am J Physiol Regul Integr Comp Physiol. 2002 Jan;282(1):R156-65. doi: 10.1152/ajpregu.2002.282.1.R156.
5
[Influence of vasoactive peptides on homocysteine-induced proliferation of cultured rabbit vascular smooth muscle cell].[血管活性肽对同型半胱氨酸诱导的培养兔血管平滑肌细胞增殖的影响]
Zhonghua Yi Xue Za Zhi. 1999 Jun;79(6):411-3.
6
Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway.利钠肽如一氧化氮通过环磷酸鸟苷（cGMP）途径促进心脏迷走神经传递和心动过缓。
Am J Physiol Heart Circ Physiol. 2001 Dec;281(6):H2318-27. doi: 10.1152/ajpheart.2001.281.6.H2318.
7
Molecular and biochemical characterization of a CNP-sensitive guanylyl cyclase in bovine tracheal smooth muscle.牛气管平滑肌中一种对C型利钠肽敏感的鸟苷酸环化酶的分子和生化特性
Am J Respir Cell Mol Biol. 2001 Jul;25(1):98-103. doi: 10.1165/ajrcmb.25.1.4395.
8
Natriuretic peptide receptors in the central vasculature of the toad, Bufo marinus.海蟾蜍（Bufo marinus）中枢脉管系统中的利钠肽受体
Comp Biochem Physiol A Mol Integr Physiol. 2001 Feb;128(2):259-68. doi: 10.1016/s1095-6433(00)00302-0.
9
ANP, BNP, and CNP enhance bradycardic responses to cardiopulmonary chemoreceptor activation in conscious sheep.心钠素、脑钠素和C型钠尿肽增强清醒绵羊对心肺化学感受器激活的心动过缓反应。
Am J Physiol Regul Integr Comp Physiol. 2001 Jan;280(1):R282-8. doi: 10.1152/ajpregu.2001.280.1.R282.
10
Organ-specific mRNA distribution of C-type natriuretic peptide in neonatal and adult mice.C型利钠肽在新生小鼠和成年小鼠体内的器官特异性mRNA分布
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C型利钠肽对不同动物胃动力影响的比较研究。

Comparative study in the effect of C-type natriuretic peptide on gastric motility in various animals.

作者信息

Guo Hui-Shu, Jin Zheng, Jin Zheng-Yuan, Li Zhe-Hao, Cui Yi-Feng, Wang Zuo-Yu, Xu Wen-Xie

机构信息

Department of Physiology, Yanbian University College of Medicine, Juzi 121, Yanji 133000, Jilin Province, China.

出版信息

World J Gastroenterol. 2003 Mar;9(3):547-52. doi: 10.3748/wjg.v9.i3.547.

DOI:10.3748/wjg.v9.i3.547
PMID:12632516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4621580/
Abstract

AIM

To investigate the effect of natriuretic peptides on gastric motility in various animals, and the effect of C-type natriuretic peptide (CNP) on spontaneous contraction of gastric smooth muscle in rat, guinea-pig and human in vitro was compared.

METHODS

Spontaneous contraction of gastric smooth muscle was recorded by four channel physiograph.

RESULTS

In the guinea-pig and rat gastric antral circular smooth muscle, CNP markedly decreased the amplitude of spontaneous contraction but it didn't affect the frequency, however, the contractile activity was completely inhibited by CNP in gastric antral longitudinal smooth muscle. In the human gastric antral circular and longitudinal smooth musle, CNP completely inhibited spontaneous contraction. In the circular smooth muscle of guinea-pig and rat gastric fundus, CNP obviously decreased the amplitude of spontaneous contraction but it didn't affect the frequency, however, the contractile activity was completely inhibited by CNP in smooth muscle of fundus longitudinal. In the circular and longitudinal smooth muscle of guinea-pig gastric body, CNP at first induced a relaxation and then an increase in amplitude of spontaneous contraction (rebound contraction), but the frequency was not changed. After the circular smooth muscle of gastric body was pretreated with atropine, an M receptor blocker, the rebound contraction was abolished; In circular and longitudinal smooth muscle of rat gastric body, CNP induced a transient and slight relaxation and successively followed by the recovery in amplitude of spontaneous contraction but it also didn't affect the frequency. After the smooth muscle was pretreated with atropine, the transient and slight relaxation was replaced by long term and complete inhibition; The percentage of CNP-induced inhibition was 76.77+/-6.21 % (fundus), 67.21+/-5.32 % (body) and 58.23+/- 6.21 % (antral) in the gastric circular muscle, however, the inhibitory percentage was 100+/-0.00 % (fundus), 68.66+/- 3.55 % (body) and 100+/-0.00 % (antrum) in the gastric longitudinal smooth muscle of guinea-pigs; In the rat, the percentage of CNP-induced inhibition was 95.87+/-4.12 % (fundus), 94.91+/-5.08 % (body) and 66.32+/-7.32 % (antrum)in the gastric circular smooth muscle, but in the longitudinal smooth muscle, CNP completely inhibited the spontaneous contraction. Using LY83583, a guanylate cyclase inhibitor, and zaparinast as a phosphoesterase inhibitor to inhibit the generation of cGMP, the effect of CNP on the spontaneous contraction was markedly weakened by LY83583, however, the inhibitory effect was enhanced by zaparinast.

CONCLUSION

(1) CNP can obviously inhibit the spontaneous contraction of gastric antral circular and longitudinal smooth muscle in the rat, guinea-pig and human. The order of inhibitory potency is human >rat> guinea-pig. (2) In the same animals, the inhibitory effect of CNP on spontaneous contraction is the most powerful in fundus and the weakest in antrum, in the same position, the inhibitory effect on the circular smooth muscle is more powerful than that on longitudinal smooth muscle. (3) The inhibitory effect of CNP on spontaneous contraction in the gastric smooth muscle is mediated by a cGMP dependent pathway.

摘要

目的

研究利钠肽对多种动物胃动力的影响，并比较C型利钠肽（CNP）对大鼠、豚鼠和人胃平滑肌自发性收缩的影响。

方法

用四道生理记录仪记录胃平滑肌的自发性收缩。

结果

在豚鼠和大鼠胃窦环形平滑肌中，CNP显著降低自发性收缩幅度，但不影响频率，然而，在胃窦纵行平滑肌中CNP完全抑制收缩活性。在人胃窦环形和纵行平滑肌中，CNP完全抑制自发性收缩。在豚鼠和大鼠胃底环形平滑肌中，CNP明显降低自发性收缩幅度，但不影响频率，然而，在胃底纵行平滑肌中CNP完全抑制收缩活性。在豚鼠胃体环形和纵行平滑肌中，CNP起初引起舒张，随后自发性收缩幅度增加（反跳性收缩），但频率不变。胃体环形平滑肌用M受体阻断剂阿托品预处理后，反跳性收缩消失；在大鼠胃体环形和纵行平滑肌中，CNP引起短暂轻微舒张，随后自发性收缩幅度恢复，但也不影响频率。平滑肌用阿托品预处理后，短暂轻微舒张被长期完全抑制所取代；在胃环形平滑肌中，CNP诱导的抑制百分率在豚鼠中为胃底76.77±6.21%、胃体67.21±5.32%、胃窦58.23±6.21%，然而，在豚鼠胃纵行平滑肌中抑制百分率为胃底100±0.00%、胃体68.66±3.55%、胃窦100±0.00%；在大鼠中，CNP在胃环形平滑肌中诱导的抑制百分率为胃底95.87±4.12%、胃体94.91±5.08%、胃窦66.32±7.32%，但在纵行平滑肌中，CNP完全抑制自发性收缩。用鸟苷酸环化酶抑制剂LY83583和磷酸二酯酶抑制剂扎普司特抑制cGMP生成，LY83583使CNP对自发性收缩的作用明显减弱，然而，扎普司特增强抑制作用。

结论

（1）CNP能明显抑制大鼠、豚鼠和人胃窦环形和纵行平滑肌的自发性收缩。抑制效力顺序为人类＞大鼠＞豚鼠。（2）在同一动物中，CNP对自发性收缩的抑制作用在胃底最强，胃窦最弱，在同一部位，对环形平滑肌的抑制作用比对纵行平滑肌更强。（3）CNP对胃平滑肌自发性收缩的抑制作用由cGMP依赖性途径介导。