Kalogerakis Aris, Groth Ulrich
Fachbereich Chemie, Universität Konstanz, Fach M-720, Universitaetsstrasse 10, 78457 Konstanz, Germany.
Org Lett. 2003 Mar 20;5(6):843-4. doi: 10.1021/ol0274920.
[reaction: see text] A general method for the synthesis of benz[a]anthraquinones is reported. The key step is a catalytic cobalt-mediated [2+2+2]-cycloaddition of a triyne, which affords an angularly substituted tetracycle. Oxidation of this core gives the typical structure of angucyclinone antibiotics.
