Peters M, Tenhündfeld J, Stephan I, Hewicker-Trautwein M
Clinic for Small Domestic Animals, School of Veterinary Medicine, Bischofsholer Damm 15, D-30173, Hannover, Germany
J Comp Pathol. 2003 Feb-Apr;128(2-3):107-12. doi: 10.1053/jcpa.2002.0612.
Embolized mesothelial-like cells were detected within pericardial lymphatics and mediastinal lymph nodes of three golden retrievers with idiopathic haemorrhagic pericardial effusion. Morphological, cytochemical, and immunohistochemical investigations indicated that the embolized cells most likely originated from the pericardial mesothelium. None of the dogs showed evidence of an underlying neoplastic disorder. Such findings have not been reported previously in animals, but so-called "benign mesothelial cell inclusions" have been reported in mediastinal lymph nodes of human patients with pleuritis and pericarditis but no history of neoplasia. The present findings in dogs indicate the need to distinguish between lymphatic emboli arising from reactive mesothelial cells and metastases arising from a mesothelioma.
在三只患有特发性出血性心包积液的金毛猎犬的心包淋巴管和纵隔淋巴结中检测到栓塞的间皮样细胞。形态学、细胞化学和免疫组织化学研究表明，栓塞细胞很可能起源于心包间皮。这些犬均未显示潜在肿瘤性疾病的证据。此类发现此前在动物中未见报道，但在无肿瘤病史的胸膜炎和心包炎人类患者的纵隔淋巴结中曾报道过所谓的“良性间皮细胞包涵体”。犬的目前这些发现表明，有必要区分由反应性间皮细胞引起的淋巴栓子和间皮瘤转移。
