一头小母牛患脑原始神经外胚层肿瘤。

Cerebral primitive neuroectodermal tumour in a heifer.

作者信息

Lucas M-N, Nguyen F, Abadie J, Kane Y, Cuillière P, Wyers M

机构信息

Unité d'Anatomie Pathologique, Ecole Nationale Vétérinaire de Nantes, Atlanpôle, La Chantrerie, BP 40706 F-44307, Nantes cedex 03, France.

出版信息

J Comp Pathol. 2003 Feb-Apr;128(2-3):195-8. doi: 10.1053/jcpa.2002.0611.

DOI:10.1053/jcpa.2002.0611

PMID:12634099

Abstract

A primitive neuroectodermal tumour (PNET) replacing the thalamus was discovered in an 18-month-old Prim'Holstein heifer. Microscopical examination of the tumour showed large sheets of densely packed cells with occasional Homer-Wright and perivascular rosettes. Neoplastic cells were small with ill-defined borders, scant cytoplasm and ovoid, irregularly shaped nuclei. Immunolabelling was positive for vimentin and neuron-specific enolase, in agreement with previous reports of PNETs in human beings and animals. This appears to be the first report of cerebral PNET in cattle.

摘要

在一头18个月大的Prim'Holstein小母牛中发现了一个取代丘脑的原始神经外胚层肿瘤（PNET）。对该肿瘤进行显微镜检查，可见大片紧密排列的细胞，偶尔可见霍纳-赖特（Homer-Wright）菊形团和血管周围菊形团。肿瘤细胞较小，边界不清，胞质稀少，细胞核呈卵圆形、形状不规则。免疫标记显示波形蛋白和神经元特异性烯醇化酶呈阳性，这与之前关于人和动物PNET的报道一致。这似乎是牛脑PNET的首例报道。