Ark1/Prk1蛋白激酶家族。内吞作用和肌动蛋白骨架的调节因子。
The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton.
作者信息
Smythe Elizabeth, Ayscough Kathryn R
机构信息
Centre for Developmental Genetics, Department of Biomedical Sciences, University of Sheffield, Sheffield S10 2TN, UK.
出版信息
EMBO Rep. 2003 Mar;4(3):246-51. doi: 10.1038/sj.embor.embor776.
Abstract
The Ark/Prk serine/threonine kinases initiate phosphorylation cycles that control the endocytic machinery in mammalian cells and in yeast, and the actin cytoskeleton in yeast. The members of this protein family are unified by homologies in their kinase domain, but are generally diverse in their other domains. The evolution of Ark/Prk family members in different organisms may have allowed the conserved role of the kinase domain, which is required for the phosphorylation of both endocytic and cytoskeletal components, to be coupled to other functional domains.
摘要
Ark/Prk丝氨酸/苏氨酸激酶启动磷酸化循环，该循环控制哺乳动物细胞和酵母中的内吞机制以及酵母中的肌动蛋白细胞骨架。这个蛋白质家族的成员在其激酶结构域具有同源性，但在其他结构域通常各不相同。不同生物体中Ark/Prk家族成员的进化可能使激酶结构域的保守作用（内吞和细胞骨架成分磷酸化所必需的）与其他功能结构域相结合。
相似文献
1
The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton.Ark1/Prk1蛋白激酶家族。内吞作用和肌动蛋白骨架的调节因子。
EMBO Rep. 2003 Mar;4(3):246-51. doi: 10.1038/sj.embor.embor776.
2
Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells.内吞性Ark/Prk激酶在酵母和哺乳动物细胞的阿霉素抗性中都起着关键作用。
Cancer Res. 2006 Dec 15;66(24):11932-7. doi: 10.1158/0008-5472.CAN-06-3220.
3
Coupling actin dynamics to the endocytic process in Saccharomyces cerevisiae.将肌动蛋白动力学与酿酒酵母中的内吞作用过程相耦合。
Protoplasma. 2005 Oct;226(1-2):81-8. doi: 10.1007/s00709-005-0107-5. Epub 2005 Oct 20.
4
In vivo role for actin-regulating kinases in endocytosis and yeast epsin phosphorylation.肌动蛋白调节激酶在胞吞作用和酵母 epsin 磷酸化中的体内作用。
Mol Biol Cell. 2001 Nov;12(11):3668-79. doi: 10.1091/mbc.12.11.3668.
5
Target of rapamycin complex 2-dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in .Akl1 通过雷帕霉素复合物 2 依赖性磷酸化 Pan1 衣壳蛋白来控制. 的内吞动力学。
J Biol Chem. 2018 Aug 3;293(31):12043-12053. doi: 10.1074/jbc.RA117.001615. Epub 2018 Jun 12.
6
Conserved Ark1-related kinases function in a TORC2 signaling network.保守的 Ark1 相关激酶在 TORC2 信号网络中发挥作用。
Mol Biol Cell. 2020 Aug 15;31(18):2057-2069. doi: 10.1091/mbc.E19-12-0685. Epub 2020 Jul 2.
7
Prk1p.蛋白激酶1p
Int J Biochem Cell Biol. 2005 Jan;37(1):48-53. doi: 10.1016/j.biocel.2004.03.010.
8
Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis.Scd5 作为一种蛋白磷酸酶-1 靶向蛋白，在 Sla1 内吞作用过程中的磷酸化调节中的作用。
J Cell Sci. 2012 Oct 15;125(Pt 20):4728-39. doi: 10.1242/jcs.098871. Epub 2012 Jul 23.
9
An endocytic Prk-ing brake.一种内吞性的Prk制动机制。
Nat Cell Biol. 2005 Mar;7(3):210-2. doi: 10.1038/ncb0305-210.
10
Regulation of yeast actin cytoskeleton-regulatory complex Pan1p/Sla1p/End3p by serine/threonine kinase Prk1p.丝氨酸/苏氨酸激酶Prk1p对酵母肌动蛋白细胞骨架调节复合物Pan1p/Sla1p/End3p的调控
Mol Biol Cell. 2001 Dec;12(12):3759-72. doi: 10.1091/mbc.12.12.3759.
引用本文的文献
1
The Yeast Gsk-3 Kinase Mck1 Is Necessary for Cell Wall Remodeling in Glucose-Starved and Cell Wall-Stressed Cells.酵母Gsk-3激酶Mck1在葡萄糖饥饿和细胞壁应激细胞的细胞壁重塑中是必需的。
Int J Mol Sci. 2025 Apr 9;26(8):3534. doi: 10.3390/ijms26083534.
2
Curcumin prevents dexamethasone-induced activation of the pseudorabies virus in rat pheochromocytoma cells through the miR-155-5p-Aak1-Numb/Notch2 signalling axis.姜黄素通过miR-155-5p-Aak1-Numb/Notch2信号轴预防地塞米松诱导的大鼠嗜铬细胞瘤细胞中伪狂犬病病毒的激活。
Vet Res. 2025 Apr 21;56(1):86. doi: 10.1186/s13567-025-01509-9.
3
Loss of cytoplasmic actin filaments raises nuclear actin levels to drive INO80C-dependent chromosome fragmentation.细胞质肌动蛋白丝的丧失会提高核肌动蛋白水平，从而驱动 INO80C 依赖性染色体片段化。
Nat Commun. 2024 Nov 15;15(1):9910. doi: 10.1038/s41467-024-54141-0.
4
SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity.SEL-5/AAK1 通过独立于其激酶活性调节细胞迁移和细胞外生。
Elife. 2024 Jul 19;13:e91054. doi: 10.7554/eLife.91054.
5
Modularly engineering for α-terpineol production.用于α-松油醇生产的模块化工程
Front Bioeng Biotechnol. 2024 Jan 19;11:1310069. doi: 10.3389/fbioe.2023.1310069. eCollection 2023.
6
Recent progress in discovery of novel AAK1 inhibitors: from pain therapy to potential anti-viral agents.新型 AAK1 抑制剂的研究进展：从疼痛治疗到潜在的抗病毒药物。
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2279906. doi: 10.1080/14756366.2023.2279906. Epub 2023 Nov 13.
7
Mechanistic-Based Classification of Endocytosis-Related Inhibitors: Does It Aid in Assigning Drugs against SARS-CoV-2?基于机制的内吞作用相关抑制剂分类：它有助于对抗 SARS-CoV-2 的药物分类吗？
Viruses. 2023 Apr 23;15(5):1040. doi: 10.3390/v15051040.
8
Current thoughts on cellular functions of numb-associated kinases.目前关于 Numb 相关激酶的细胞功能的思考。
Mol Biol Rep. 2023 May;50(5):4645-4652. doi: 10.1007/s11033-023-08372-x. Epub 2023 Apr 4.
9
lncRNA ZFAS1 promotes intervertebral disc degeneration by upregulating AAK1.长链非编码RNA ZFAS1通过上调AAK1促进椎间盘退变。
Open Med (Wars). 2022 Dec 9;17(1):1973-1986. doi: 10.1515/med-2022-0530. eCollection 2022.
10
Eps15/Pan1p is a master regulator of the late stages of the endocytic pathway.Eps15/Pan1p 是内吞作用晚期阶段的主要调控因子。
J Cell Biol. 2022 Oct 3;221(10). doi: 10.1083/jcb.202112138. Epub 2022 Aug 19.
本文引用的文献
1
Protein phosphatase-1 binding to scd5p is important for regulation of actin organization and endocytosis in yeast.蛋白磷酸酶-1与scd5p的结合对于酵母中肌动蛋白组织和内吞作用的调节很重要。
J Biol Chem. 2002 Dec 13;277(50):48002-8. doi: 10.1074/jbc.M208471200. Epub 2002 Sep 27.
2
Endocytosis and the cytoskeleton.内吞作用与细胞骨架
Int Rev Cytol. 2002;220:93-144. doi: 10.1016/s0074-7696(02)20004-2.
3
Imaging actin and dynamin recruitment during invagination of single clathrin-coated pits.在单个网格蛋白包被小窝内陷过程中对肌动蛋白和发动蛋白募集进行成像。
Nat Cell Biol. 2002 Sep;4(9):691-8. doi: 10.1038/ncb837.
4
The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila.内吞蛋白α-衔接蛋白是果蝇中麻木介导的不对称细胞分裂所必需的。
Dev Cell. 2002 Aug;3(2):221-31. doi: 10.1016/s1534-5807(02)00215-0.
5
Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast.Scd5p和网格蛋白的功能对于酵母中皮质肌动蛋白的组织、内吞作用以及sla2p的定位很重要。
Mol Biol Cell. 2002 Aug;13(8):2607-25. doi: 10.1091/mbc.e02-01-0012.
6
Cellular control of actin nucleation.肌动蛋白成核的细胞控制。
Annu Rev Cell Dev Biol. 2002;18:247-88. doi: 10.1146/annurev.cellbio.18.040202.112133. Epub 2002 Apr 2.
7
Molecular architecture and functional model of the endocytic AP2 complex.内吞作用AP2复合体的分子结构与功能模型
Cell. 2002 May 17;109(4):523-35. doi: 10.1016/s0092-8674(02)00735-3.
8
CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles.酪蛋白激酶2（CK2）和GAK/辅助蛋白2是网格蛋白包被小泡中的主要蛋白激酶。
Traffic. 2002 Jun;3(6):428-39. doi: 10.1034/j.1600-0854.2002.30606.x.
9
Sla1p couples the yeast endocytic machinery to proteins regulating actin dynamics.Sla1p将酵母内吞作用机制与调节肌动蛋白动力学的蛋白质联系起来。
J Cell Sci. 2002 Apr 15;115(Pt 8):1703-15. doi: 10.1242/jcs.115.8.1703.
10
Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis.Sla1p作为NPFX(1,2)D介导的内吞作用的靶向信号识别因子。
J Cell Biol. 2002 Apr 15;157(2):315-26. doi: 10.1083/jcb.200110027. Epub 2002 Apr 8.
Zotero 插件