Schmidt Ulrike, Meier Nicola, Weisser Hans-Joachim, Knoblich Annette, Graw Matthias
Institut für Rechtsmedizin, Universität Freiburg.
Arch Kriminol. 2003 Jan-Feb;211(1-2):42-7.
By application of Y-chromosomal STRs, DNA analysis of abortion material can be considerably facilitated since great excess of maternal DNA is tolerated without disturbing the Y-STR amplification. If paternity can't be excluded on the basis of the Y-STR haplotype, further examinations must follow, e.g. autosomal STR analysis. For this purpose, histological preparation of the abortion tissue might still be necessary. Different Y-chromosomal haplotypes of embryo and putative father usually lead to an exclusion from paternity. Based on four case examples, the feasibility of this method is discussed.
通过应用Y染色体短串联重复序列（Y-chromosomal STRs），流产材料的DNA分析可以得到极大便利，因为即使存在大量过量的母体DNA，也不会干扰Y-STR扩增。如果根据Y-STR单倍型不能排除父系关系，则必须进行进一步检查，例如常染色体STR分析。为此，可能仍需要对流产组织进行组织学制备。胚胎和推定父亲的不同Y染色体单倍型通常会导致排除父系关系。基于四个案例，讨论了该方法的可行性。
