Mohri H, Ishitoya T, DiBenedetto G, Hessel E A, Merendino K A, Dillard D H
J Thorac Cardiovasc Surg. 1976 May;71(5):792-9.
To facilitate perfusion rewarming without the use of total body heparinization or an oxygenator following open-heart correction with surface hypothermia, we divised a pump circuit. The circuit, totally primed with 100 c.c. of saline, consists of polyurethane-polyvinyl-graphite (PPG) coated Tygon tubes (with one end tapered by heat treatment) and a copper-coil heat exchanger. A roller pump was used to achieve partial bypass from the left atrium to the ascending aorta with flow rates up to 70 c.c. per kilogram per minute. Experiments in dogs resulted in rapid rewarming, immediate return of cardiac function, and hematologic alterations similar to those noted during surface rewarming. The safety of the method was also demonstrated. Prothrombin time, partial thromboplastin time, and platelet values returned to control levels upon rewarming, and no thromboemboli or bleeding problems were noted. Six clinical experiences were accumulated. Details of the method, hematologic and blood chemical analyses in dogs, and the first clinical trial in a 3-month-old infant with transposition of the great vessels are reported.
为便于在体表低温下心内直视矫正术后不使用全身肝素化或体外循环进行灌注复温，我们设计了一种泵回路。该回路用100毫升生理盐水预充，由涂有聚氨酯 - 聚乙烯 - 石墨（PPG）的泰贡管（一端经热处理变细）和铜盘管热交换器组成。使用滚压泵实现从左心房到升主动脉的部分旁路，流速可达每分钟每千克70毫升。犬实验结果显示复温迅速、心功能立即恢复，血液学改变与体表复温时相似。该方法的安全性也得到了证实。复温后凝血酶原时间、部分凝血活酶时间和血小板值恢复到对照水平，未发现血栓栓塞或出血问题。积累了6例临床经验。报告了该方法的细节、犬的血液学和血液化学分析，以及对一名3个月大患大血管转位婴儿的首次临床试验情况。
