Lintern-Moore S, Pantelouris E M
Mech Ageing Dev. 1976 Jan-Feb;5(1):33-8. doi: 10.1016/0047-6374(76)90005-1.
The response of 1 month old congenitally athymic nude mice and their phenotypically normal littermates to exogenous pregnant mare serum gonadotrophin (PMSG) and oestradiol-17beta has been tested. An equal increase in the number of growing follicles was detected in both nudes and controls in response to PMSG. A specific increase occurred in the number of unilaminar follicles in the initial growth stages in addition to the increase in the number of multilaminar and vesicular follicles. Oestradiol depressed follicular growth equally in both nudes and controls. The contracted appearance of growing follicles in nudes disappeared under the influence of PMSG and was induced in ovaries of control mice treated with oestradiol. We conclude that the ability of the mouse ovary to respond to exogenous PMSG and the oestradiol is not impaired by congenital athymia as expressed in the nude genotype. The data suggest that the retardation of follicular growth already reported in 1 month old nudes arises from a deficiency of gonadotrophin.
对1月龄先天性无胸腺裸鼠及其表型正常的同窝仔鼠对外源性孕马血清促性腺激素（PMSG）和雌二醇-17β的反应进行了检测。在对PMSG的反应中，裸鼠和对照组中生长卵泡的数量均有同等程度的增加。除了多层卵泡和囊状卵泡数量增加外，初始生长阶段的单层卵泡数量也有特定增加。雌二醇对裸鼠和对照组的卵泡生长抑制作用相同。在PMSG的影响下，裸鼠中生长卵泡的收缩外观消失，而在用雌二醇处理的对照小鼠卵巢中则诱导出现这种外观。我们得出结论，裸基因型所表现出的先天性无胸腺并不损害小鼠卵巢对外源性PMSG和雌二醇的反应能力。数据表明，已有报道的1月龄裸鼠卵泡生长迟缓是由促性腺激素缺乏所致。
