A study of the freeze-drying conditions of calixarene based solid lipid nanoparticles.
作者信息
Shahgaldian Patrick, Gualbert Jérôme, Aïssa Kaïs, Coleman Anthony W
机构信息
Institut de Biologie et Chimie des Protéines, Lyon, France.
出版信息
Eur J Pharm Biopharm. 2003 Mar;55(2):181-4. doi: 10.1016/s0939-6411(02)00196-0.
Abstract
In this note, we report a study of cryoprotectant carbohydrate (glucose, fructose, mannose and maltose) effects on the reconstitution of calixarene based solid lipid nanoparticle (SLN) suspensions after freeze-drying, studied by atomic force microscopy and photon correlation spectroscopy. All carbohydrates tested showed excellent cryoprotection and redispersion properties with the calixarene based SLNs.
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