Podolec Piotr, Tomkiewicz-Pajak Lidia, Pieculewicz Monika, Barczyk Edyta, Tarkota Piotr, Kaźnica Magdalena, Pasowicz Mieczysław, Olszowska Maria, Tracz Wiesława
Klinika Chorób Serca i Naczyń Instytutu Kardiologii Collegium Medicum Uniwersytetu Jagiellońskiego, 31-202 Kraków, ul. Pradnicka 80.
Przegl Lek. 2002;59(8):580-2.
The aim of the study was to determine the degree of reproducibility of parameters of cardiopulmonary exercise (CPX) tests in patients with chronic heart failure (HF).
We investigated 30 patients (7 women, 23 men) with ages ranging from 44 to 68 and a mean age of 56 +/- 14.5 years with HF due to dilated cardiomyopathy (5 patients) and coronary artery diseases (25 patients). The mean ejection fraction was 24 +/- 6.2%. All the patients were symptomatically stable during the preceding 4 weeks. After a preliminary test, the patients underwent two treadmill CPX tests using modified Naughton protocol with a 1-week interval between tests. CPX tests were performed at the same time of the day, using the same equipment and the patients were receiving constant medication. The reproducibility was assessed for: Rest heart rate (HRrest), oxygen uptake at the anaerobic threshold (VO2AT) and peak exercise (VO2peak), carbon dioxide production (VCO2peak), ventilatory equivalent of carbon dioxide (VE/VCO2peak) and oxygen (VE/VO2peak), end-tidal partial pressure for carbon dioxide (PETCO2peak), exercise time (T) and respiratory exchange ratio (RER).
The reproducibility was found for all analyzed parameters of CPX tests: HRpeak (p < 0.0001), VO2AT (p < 0.0001), T (p < 0.001), HRpeak (p < 0.0001), VO2peak (p < 0.0001), VO2peak%N (p < 0.0001), VE/VCO2peak (p < 0.0001), VE/VO2peak (p < 0.0001), PETCO2peak (p < 0.0001), RER (p < 0.004).
On adherence to standardized conditions, an excellent reproducibility exists for the most important parameters of cardiopulmonary exercise tests. CPX tests provide a useful and objective method of assessing functional capacity and diseases progression in patients with heart failure.
本研究旨在确定慢性心力衰竭（HF）患者心肺运动（CPX）测试参数的可重复性程度。
我们调查了30例患者（7名女性，23名男性），年龄在44至68岁之间，平均年龄为56±14.5岁，患有扩张型心肌病导致的HF（5例）和冠状动脉疾病导致的HF（25例）。平均射血分数为24±6.2%。所有患者在之前4周内症状稳定。经过初步测试后，患者使用改良的诺顿方案进行了两次跑步机CPX测试，两次测试间隔1周。CPX测试在一天中的同一时间进行，使用相同的设备，并且患者持续接受药物治疗。对以下参数评估了可重复性：静息心率（HRrest）、无氧阈值时的摄氧量（VO2AT）和峰值运动时的摄氧量（VO2peak）、二氧化碳产生量（VCO2peak）、二氧化碳通气当量（VE/VCO2peak）和氧气通气当量（VE/VO2peak）、呼气末二氧化碳分压（PETCO2peak）、运动时间（T）和呼吸交换率（RER）。
发现CPX测试的所有分析参数均具有可重复性：HRpeak（p<0.0001）、VO2AT（p<0.0001）、T（p<0.001）、HRpeak（p<0.0001）、VO2peak（p<0.0001）、VO2peak%N（p<0.0001）、VE/VCO2peak（p<0.0001）、VE/VO2peak（p<0.0001）、PETCO2peak（p<0.0001）、RER（p<0.004）。
在遵循标准化条件的情况下，心肺运动测试的最重要参数具有出色的可重复性。CPX测试为评估心力衰竭患者的功能能力和疾病进展提供了一种有用且客观的方法。
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