模拟胃肠道癌相关表位CO17-1A的单克隆抗独特型抗体在结直肠癌患者中引发抗原特异性体液免疫和细胞免疫反应。
Monoclonal anti-idiotypic antibody mimicking the gastrointestinal carcinoma-associated epitope CO17-1A elicits antigen-specific humoral and cellular immune responses in colorectal cancer patients.
作者信息
Birebent Brigitte, Mitchell Edith, Akis Nese, Li Weiping, Somasundaram Rajasekharan, Purev Enkhtsetseg, Hoey Diane, Mastrangelo Michael, Maguire Henry, Harris David T, Nair Sridhar, Cai Dewei, Zhang Tianqian, Herlyn Dorothee M
机构信息
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
出版信息
Vaccine. 2003 Apr 2;21(15):1601-12. doi: 10.1016/s0264-410x(02)00752-1.
Monoclonal rat anti-idiotypic antibody (Ab2) BR3E4 mimicking the colorectal carcinoma (CRC)-associated epitope CO17-1A induced antigen-specific humoral and cellular immune responses in mice and rabbits. Ab2 BR3E4 was administered in a phase I trial to CRC patients either as intact IgG or as F(ab')(2) coupled to keyhole limpet hemocyanin (KLH). There was a trend for the F(ab')(2)-KLH-immunized patients to show higher immune response rates (18/21 and 5/15 patients with anti-anti-idiotypic antibodies and T cells, respectively) than the IgG-immunized patients (15/23 and 3/15 patients positive). Clinical responses were rare in these patients with liver metastases.
模拟结肠直肠癌（CRC）相关表位CO17 - 1A的单克隆大鼠抗独特型抗体（Ab2）BR3E4在小鼠和兔子中诱导了抗原特异性体液免疫和细胞免疫反应。Ab2 BR3E4在一项I期试验中以完整IgG或与钥孔戚血蓝蛋白（KLH）偶联的F(ab')₂形式给予CRC患者。与接受IgG免疫的患者（分别有15/23和3/15例阳性）相比，接受F(ab')₂ - KLH免疫的患者有显示出更高免疫反应率的趋势（分别有18/21和5/15例患者产生抗抗独特型抗体和T细胞）。这些有肝转移的患者临床反应罕见。
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