Synthesis of N,N',N"-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor. - Suppr | 超能文献

Synthesis of N,N',N"-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor.

作者信息

Park Hyeung-geun, Park Mi-kyung, Choi Ji-yeon, Choi Sea-hoon, Lee Jihye, Park Boon-saeng, Kim Myoung Goo, Suh Young-ger, Cho Hawon, Oh Uhtaek, Lee Jeewoo, Kim Hee-Doo, Park Young-Ho, Koh Hyun-Ju, Lim Kyung Min, Moh Joo-Hyun, Jew Sang-sup

机构信息

Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, South Korea.

出版信息

Bioorg Med Chem Lett. 2003 Feb 24;13(4):601-4. doi: 10.1016/s0960-894x(02)01040-5.

DOI:10.1016/s0960-894x(02)01040-5

Abstract

Twenty-seven N,N',N"-trisubstituted thiourea derivatives were prepared. Among them, 1-[3-(4'-hydroxy-3'-methoxy-phenyl)-propyl]-1,3-diphenethyl-thiourea (8l, IC(50)=0.32 microM), showed 2-fold higher antagonistic activity than that of capsazepine (3, IC(50)=0.65 microM) against the vanilloid receptor in a (45)Ca(2+)-influx assay.

摘要

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