Yoon JungWha, Choi HyeYoung, Lee Hyun Joo, Ryu Chong Hyun, Park Hyeung-geun, Suh Young-ger, Oh Uhtaek, Jeong Yeon Su, Choi Jin Kyu, Park Young-Ho, Kim Hee-Doo
College of Pharmacy, Sookmyung Women's University, 53-12 Chungpa-dong, Yongsan-ku, Seoul 140-742, South Korea.
Bioorg Med Chem Lett. 2003 May 5;13(9):1549-52. doi: 10.1016/s0960-894x(03)00178-1.
A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched 1e showed a 6.3 microM of IC(50) value in 45Ca(2+)-influx assay.
已经合成了一系列无环苯乙硫代氨基甲酸盐衍生物，并测试了它们对香草酸受体的拮抗作用。链分支导致母体分子的拮抗活性发生显著变化。在45Ca(2+)流入测定中，乙基分支的1e显示出6.3微摩尔的IC(50)值。
