可能的多发性硬化症中的认知障碍
Cognitive impairment in probable multiple sclerosis.
作者信息
Achiron A, Barak Y
机构信息
Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, 52621 Israel.
出版信息
J Neurol Neurosurg Psychiatry. 2003 Apr;74(4):443-6. doi: 10.1136/jnnp.74.4.443.
Abstract
OBJECTIVES
To evaluate and characterise cognitive impairment in the very early stage of multiple sclerosis (MS), in which patients are still diagnosed as suffering from probable MS.
METHODS
The Brief Repeatable Battery-Neuropsychological (BRB-N) that has been validated for MS patients was used. Abnormal performance was defined as one standard deviation below the mean reported for healthy age matched subjects. Neurological disability and brain magnetic resonance imaging (MRI) were performed for all patients. Correlation coefficients were calculated between disease burden variables and performance on the BRB-N.
RESULTS
Sixty seven patients with probable MS were evaluated within a mean of one month of the onset of new neurological symptoms. Evidence for the presence of cognitive impairment was shown in 53.7% of patients. Verbal abilities and attention span were most frequently affected. Impairment was not correlated with neurological disability or MRI disease burden.
CONCLUSION
Prevalent cognitive impairment already exists at onset of MS.
摘要
目的
评估和描述多发性硬化症（MS）极早期的认知障碍，此时患者仍被诊断为可能患有MS。
方法
使用已在MS患者中验证的简短重复神经心理测验（BRB-N）。异常表现定义为比年龄匹配的健康受试者报告的平均值低一个标准差。对所有患者进行神经功能残疾评估和脑磁共振成像（MRI）检查。计算疾病负担变量与BRB-N测试表现之间的相关系数。
结果
67例可能患有MS的患者在出现新神经症状后平均1个月内接受了评估。53.7%的患者存在认知障碍证据。语言能力和注意力最常受到影响。认知障碍与神经功能残疾或MRI疾病负担无关。
结论
MS发病时即已存在普遍的认知障碍。
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