Dackovic Jelena, Pekmezovic Tatjana, Mesaros Sarlota, Dujmovic Irena, Stojsavljevic Nebojsa, Martinovic Vanja, Drulovic Jelena
Clinic of Neurology, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Dr Subotica 6, Belgrade, 11000, Serbia.
Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Neurol Sci. 2016 Sep;37(9):1475-81. doi: 10.1007/s10072-016-2610-1. Epub 2016 May 20.
Cognitive impairment is prevalent in multiple sclerosis (MS) occurring in 43-72 % of patients with all MS phenotypes. The aim of our study was to assess cognitive performance in different MS subtypes in Serbian population. Rao's Brief Repeatable Battery of neuropsychological tests (BRB-N) was administered to 168 MS patients [37 patients with clinically isolated syndrome (CIS) suggestive of MS, 65 with relapsing-remitting MS (RRMS), 31 with secondary progressive MS (SPMS) and 35 patients with primary progressive MS (PPMS)]. The percentage of cognitively impaired patients in our total MS cohort was 58.9 %. Prevalence of cognitive dysfunction was 40.5 % in CIS group, 36.9 % in RRMS, 96.8 % in SPMS, and 85.7 % in PPMS group. Patients in CIS and RRMS groups performed consistently better all tests of the Rao's battery than patients in SPMS and PPMS cohort. CIS and RRMS groups performed consistently better in all tests of the Rao's battery than SPMS and PPMS cohort. Additionally, difference in the performance of any of the BRB-N tests was not found between CIS and RRMS. However, there was a significant difference between SPMS and PPMS patients in the performance on five tests of Rao's battery. Statistical significance (p < 0.05) in favor of PPMS patients was demonstrated for the following tasks: SRT_lts, SRT_cltr, SDMT, SRT_D, SPART_D. Our study demonstrates that cognitive impairment is frequent in all MS phenotypes. Furthermore, we have found that cognitive deficit is most severe and most frequent in SPMS patients, followed by PPMS subjects and then CIS and RRMS patients.
认知障碍在多发性硬化症（MS）中很常见，所有MS表型的患者中有43%-72%会出现认知障碍。我们研究的目的是评估塞尔维亚人群中不同MS亚型的认知表现。对168名MS患者进行了Rao简短可重复神经心理测验组合（BRB-N）[37例临床孤立综合征（CIS）提示为MS的患者，65例复发缓解型MS（RRMS）患者，31例继发进展型MS（SPMS）患者和35例原发进展型MS（PPMS）患者]。我们整个MS队列中认知受损患者的比例为58.9%。CIS组认知功能障碍的患病率为40.5%，RRMS组为36.9%，SPMS组为96.8%，PPMS组为85.7%。CIS组和RRMS组的患者在Rao测验组合的所有测试中的表现始终优于SPMS组和PPMS队列中的患者。CIS组和RRMS组在Rao测验组合的所有测试中的表现始终优于SPMS组和PPMS队列。此外，未发现CIS组和RRMS组在任何BRB-N测试的表现上存在差异。然而，SPMS组和PPMS组患者在Rao测验组合的五项测试表现上存在显著差异。在以下任务中显示出有利于PPMS患者的统计学显著性（p<0.05）：SRT_lts、SRT_cltr、SDMT、SRT_D、SPART_D。我们的研究表明，认知障碍在所有MS表型中都很常见。此外，我们发现认知缺陷在SPMS患者中最为严重和常见，其次是PPMS患者，然后是CIS和RRMS患者。
