Rosenberg Eric I, Mishra Girish, Abdelmalek Manal F
Department of Internal Medicine, University of Florida, Gainesville, FL, USA.
Transplantation. 2003 Mar 15;75(5):730-2. doi: 10.1097/01.TP.0000048491.67462.DA.
Isolated visceral angioedema is an extremely rare complication of angiotensin-converting enzyme inhibitors (ACEIs). We report the first known case of ACEI-associated visceral angioedema occurring in a liver transplant recipient who presented with acute-onset abdominal pain, nausea, vomiting, diarrhea, radiologic findings of small bowel edema, and ascites. Heightened awareness of the phenomenon of isolated ACEI-associated visceral angioedema is necessary given the increasing use of these medications for treating hypertension related to calcineurin inhibitors and the need to avoid unnecessary surgical or diagnostic interventions in solid-organ transplant recipients.
孤立性内脏血管性水肿是血管紧张素转换酶抑制剂（ACEI）极为罕见的并发症。我们报告了首例已知的与ACEI相关的内脏血管性水肿病例，该病例发生在一名肝移植受者身上，其表现为急性发作的腹痛、恶心、呕吐、腹泻、小肠水肿的影像学表现以及腹水。鉴于这些药物越来越多地用于治疗与钙调神经磷酸酶抑制剂相关的高血压，且有必要避免对实体器官移植受者进行不必要的手术或诊断干预，因此有必要提高对孤立性ACEI相关内脏血管性水肿现象的认识。
