[慢性胃炎和消化性溃疡中幽门螺杆菌babA2、cagA和vacA基因型分析]
[Analysis of babA2 cagA and vacA genotypes of Helicobacter pylori in chronic gastritis and peptic ulcer].
作者信息
Mao Hai-Yan, Fang Ping-Chu, Ye Shao-Jing
机构信息
Department of Medical Microbiology and Parasitology, College of Medical Sciences, Zhejiang University, Hangzhou 310031, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2003 Feb;32(1):29-32. doi: 10.3785/j.issn.1008-9292.2003.01.008.
OBJECTIVE
To investigate the distribution of babA2 cagA and vacA genotypes of Helicobacter pylori (Hp) in chronic gastritis and peptic ulcer and to discuss the relationship between babA2, cagA and vacA genotypes of Hp and chronic gastritis and peptic ulcer.
METHODS
babA2, cagA genotypes and vacA subtype of 58 Hp strains isolated from patients of Zhejiang province with chronic gastritis or peptic ulcer were tested by polymerase chain reaction.
RESULTS
The positive rates of babA2, cagA, vacAs1a, vacA m1 and vacA m2 of 58 Hp strains were 87.9%, 100%, 93.1%, 1.7% and 65.5%, respectively. There were no significant differences between the positive rates of babA2, vacA s1a and vacA m2 genes of Hp strains isolated from patients with chronic gastritis and peptic ulcer.
CONCLUSION
The genotypes of Hp isolated from patients of Zhejiang province were predominatly babA2 positive, cagA positive and vacA s1a/m2. The relationships between babA2, cagA and vacA genotypes of Hp and chronic gastritis and peptic ulcer can not be identified.
目的
研究幽门螺杆菌（Hp）的babA2、cagA和vacA基因型在慢性胃炎及消化性溃疡中的分布情况，并探讨Hp的babA2、cagA和vacA基因型与慢性胃炎及消化性溃疡之间的关系。
方法
采用聚合酶链反应检测从浙江省慢性胃炎或消化性溃疡患者中分离出的58株Hp菌株的babA2、cagA基因型及vacA亚型。
结果
58株Hp菌株中，babA2、cagA、vacAs1a、vacA m1和vacA m2的阳性率分别为87.9%、100%、93.1%、1.7%和65.5%。从慢性胃炎患者和消化性溃疡患者中分离出的Hp菌株的babA2、vacA s1a和vacA m2基因阳性率之间无显著差异。
结论
从浙江省患者中分离出的Hp基因型主要为babA2阳性、cagA阳性和vacA s1a/m2。无法确定Hp的babA2、cagA和vacA基因型与慢性胃炎及消化性溃疡之间的关系。
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