Brassinne A
Nouv Rev Fr Hematol. 1975 Jan-Feb;15(1):107-18.
In six patients with pernicious anemia, absorption of vitamin B12 bound to intrinsic factor was low as measured by the Schilling's test. Collection of urine was complete and the activity of intrinsic factor used was checked in other pernicious anemia patients. Nutritional deficiency, drug induced malabsorption, ileal or pancreatic diseases were excluded by clinical, radiological and biological investigations. This vitamin B12 malabsorption was selective and reversible within a few months after treatment with parenteral vitamin B12. Mechanisms of this ileal dysfunction are discussed.
在6例恶性贫血患者中，通过希林试验测定，与内因子结合的维生素B12吸收较低。尿液收集完整，且所用内因子的活性在其他恶性贫血患者中进行了检查。通过临床、放射学和生物学检查排除了营养缺乏、药物引起的吸收不良、回肠或胰腺疾病。这种维生素B12吸收不良具有选择性，且在接受胃肠外维生素B12治疗后的几个月内是可逆的。本文讨论了这种回肠功能障碍的机制。
