Guo Guanghua, Qian Kejian, Zhu Feng, Xiong Long, Wang Lianqun, Li Guohui, Zhao Weilu, Cao Yong
Burn Center, The First Affiliated Hospital of Jiangxi Medical College. Nanchang 330006, P.R. China.
Zhonghua Shao Shang Za Zhi. 2002 Dec;18(6):346-9.
To investigate the influence of high frequency partial liquid ventilation (HFJV) on the cardiopulmonary function in dogs with inhalation injury.
Sixteen mongrel dogs inflicted by hot steam inhalation were subjected to severe inhalation injury and were randomly divided into control (C) and treatment (T) groups. The dogs in both groups were all given HFJV. In addition, the dogs in T group were simultaneously supplied with perfluorocarbon liquid (3 ml/kg) into the lungs slowly via tracheal intubation for liquid ventilation. The blood gas analysis, pulmonary compliance, airway resistance and hemodynamic parameters were determined at 30, 60 and 90 minutes after ventilation.
The PaO(2) in T group increased progressively, which was significantly higher than the post-injury value at all time points (P < 0.05). While the PaO(2) in C group exhibited no difference to the post-injury value at all time points. The PaCO(2) in T group increased obviously and was higher than the post-injury value at 60 and 90 post-ventilation minutes (P < 0.05). Furthermore, the PaO(2) in all the time points in T group was a little higher than that in C group (P > 0.05) and PaCO(2) in T group was much higher than that in C group at 90 min after ventilation (P < 0.05). But there was no difference between the two groups in terms of dynamic/static pulmonary compliance and airway resistance as well as the hemodynamics.
Compared with simple HFJV, high frequency partial liquid ventilation seemed to be beneficial to the oxygenation after inhalation injury and to be no influence on the hemodynamics.
探讨高频部分液体通气（HFJV）对吸入性损伤犬心肺功能的影响。
将16只吸入热蒸汽致重度吸入性损伤的杂种犬随机分为对照组（C组）和治疗组（T组）。两组犬均给予高频部分液体通气。此外，T组犬经气管插管缓慢向肺内注入全氟碳液（3 ml/kg）进行液体通气。通气后30、60和90分钟测定血气分析、肺顺应性、气道阻力和血流动力学参数。
T组动脉血氧分压（PaO₂）逐渐升高，各时间点均显著高于伤后值（P < 0.05）。而C组各时间点PaO₂与伤后值比较差异无统计学意义。T组动脉血二氧化碳分压（PaCO₂）明显升高，通气后60和90分钟高于伤后值（P < 0.05）。此外，T组各时间点PaO₂略高于C组（P > 0.05），通气后90分钟T组PaCO₂显著高于C组（P < 0.05）。但两组在动态/静态肺顺应性、气道阻力及血流动力学方面差异无统计学意义。
与单纯高频部分液体通气相比，高频部分液体通气对吸入性损伤后的氧合似乎有益，且对血流动力学无影响。
