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The vasodilatory action of testosterone: a potassium-channel opening or a calcium antagonistic action?

作者信息

Jones Richard D, Pugh Peter J, Jones T Hugh, Channer Kevin S

机构信息

Endocrine Heart & Pituitary Group, Academic Unit of Endocrinology, Division of Genomic Medicine, The University of Sheffield, Sheffield, S10 2RX, UK.

出版信息

Br J Pharmacol. 2003 Mar;138(5):733-44. doi: 10.1038/sj.bjp.0705141.

DOI:10.1038/sj.bjp.0705141
PMID:12642373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1573742/
Abstract
摘要

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本文引用的文献

1
Testosterone propionate therapy in one hundred cases of angina pectoris.一百例心绞痛患者的丙酸睾酮治疗
J Clin Endocrinol Metab. 1946 Aug;6:549-57. doi: 10.1210/jcem-6-8-549.
2
Altered circulating hormone levels, endothelial function and vascular reactivity in the testicular feminised mouse.睾丸雌性化小鼠体内循环激素水平、内皮功能及血管反应性的改变
Eur J Endocrinol. 2003 Jan;148(1):111-20. doi: 10.1530/eje.0.1480111.
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Nongenomic testosterone calcium signaling. Genotropic actions in androgen receptor-free macrophages.
J Biol Chem. 2002 Aug 16;277(33):29600-7. doi: 10.1074/jbc.M202997200. Epub 2002 Jun 4.
4
Testosterone acts as a coronary vasodilator by a calcium antagonistic action.睾酮通过钙拮抗作用发挥冠状动脉扩张剂的作用。
J Endocrinol Invest. 2002 May;25(5):455-8. doi: 10.1007/BF03344037.
5
Pulmonary vasodilatory action of testosterone: evidence of a calcium antagonistic action.睾酮的肺血管舒张作用：钙拮抗作用的证据。
J Cardiovasc Pharmacol. 2002 Jun;39(6):814-23. doi: 10.1097/00005344-200206000-00006.
6
Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease.
Am J Cardiol. 2002 Apr 1;89(7):862-4. doi: 10.1016/s0002-9149(02)02202-6.
7
Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels.睾酮诱导的大鼠肠系膜动脉床血管舒张主要通过钾通道介导。
Br J Pharmacol. 2002 Feb;135(3):735-40. doi: 10.1038/sj.bjp.0704522.
8
Gender differences in the vasomotor effects of different steroid hormones in rat pulmonary and coronary arteries.
Horm Metab Res. 2001 Nov;33(11):645-52. doi: 10.1055/s-2001-18689.
9
Testosterone-induced relaxation of rat aorta is androgen structure specific and involves K+ channel activation.睾酮诱导的大鼠主动脉舒张具有雄激素结构特异性，并涉及钾通道激活。
J Appl Physiol (1985). 2001 Dec;91(6):2742-50. doi: 10.1152/jappl.2001.91.6.2742.
10
Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel.睾酮通过开放大电导钙激活钾通道来舒张冠状动脉。
Am J Physiol Heart Circ Physiol. 2001 Oct;281(4):H1720-7. doi: 10.1152/ajpheart.2001.281.4.H1720.