某些取代喹喔啉类抗菌剂的合成（第二部分）。
Synthesis of certain substituted quinoxalines as antimicrobial agents (Part II).
作者信息
Badran Mohga M, Abouzid Khaled A M, Hussein M H M
机构信息
Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Egypt.
出版信息
Arch Pharm Res. 2003 Feb;26(2):107-13. doi: 10.1007/BF02976653.
Several fused triazolo and ditriazoloquinoxaline derivatives such as 1-aryl-4-chloro-[1,2,4]triazolo[4,3-a]quinoxalines (3a-d), 4-alkoxy[1,2,4]triazolo[4,3-a]quinoxalines (4a,b), 4-substituted-amino-[1,2,4] triazolo[4,3-a]quinoxalines (5a-h), 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-thione (6), 4-(arylidenehydrazino)1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalines (10a-e) and [1,2,4]ditriazolo[4,3-a:3',4'-c]quinoxaline derivatives (11-13) have been synthesized and some of these derivatives were evaluated for antimicrobial and antifungal activity in vitro. It was found that compounds 3a and 9b possess potent antibacterial activity compared to the standard tetracycline.
几种稠合的三唑并和二三唑并喹喔啉衍生物，如1-芳基-4-氯-[1,2,4]三唑并[4,3-a]喹喔啉（3a-d）、4-烷氧基[1,2,4]三唑并[4,3-a]喹喔啉（4a,b）、4-取代氨基-[1,2,4]三唑并[4,3-a]喹喔啉（5a-h）、1-（芳基）-[1,2,4]三唑并[4,3-a]喹喔啉-4(5H)-硫酮（6）、4-（亚苄基肼基）-1-苯基-[1,2,4]三唑并[4,3-a]喹喔啉（10a-e）和[1,2,4]二三唑并[4,3-a:3',4'-c]喹喔啉衍生物（11-13）已被合成，并且其中一些衍生物在体外进行了抗菌和抗真菌活性评估。发现与标准四环素相比，化合物3a和9b具有强效抗菌活性。
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