噻唑啉基、噻唑烷二酮基喹喔啉及1,2,4-三唑并[4,3-a]喹喔啉的合成与抗菌测试
Synthesis and antimicrobial testing of thiazolinyl-, thiazolidinonyl-quinoxalines and 1,2,4-triazolo[4,3-a]quinoxalines.
作者信息
Habib N S, el-Hawash S A
机构信息
Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Egypt.
出版信息
Pharmazie. 1997 Aug;52(8):594-8.
Three novel series of quinoxaline derivatives namely 1-substituted amino-4-phenyl-1,2,4-triazolo[4,3-a]quinoxalines 3a-c, 2-[3,4,5-trisubstituted-2,3-dihydrothiazol-2-ylidene) hydrazono]-3-phenylquinoxalines 4a-j, 5a-e, and 2-[(3-substituted-4-oxothiazolidin-2-ylidene) hydrazone]-3-phenylquinoxalines 6a-e have been synthesized by cyclization of the key intermediates 2-substituted thiocarbamoylhydrazino-3-phenylquinoxalines 2a-e. The prepared compounds were tested in vitro for their antimicrobial activity.
合成了三个新型喹喔啉衍生物系列，即1-取代氨基{"name":"GodelPlugin","parameters":{"input":"TeXForm[SubscriptBox["1","-"]]"}}<|FunctionExecuteEnd|><|FunctionExecuteResult|>₁<|FunctionExecuteResultEnd|>-取代氨基-4-苯基-1,2,4-三唑并[4,3-a]喹喔啉3a - c、2 - [(3,4,5-三取代-2,3-二氢噻唑-2-亚基)腙]-3-苯基喹喔啉4a - j、5a - e以及2 - [(3-取代-4-氧代噻唑烷-2-亚基)腙]-3-苯基喹喔啉6a - e，方法是将关键中间体2-取代硫代氨基甲酰肼基-3-苯基喹喔啉2a - e环化。对所制备的化合物进行了体外抗菌活性测试。
Zotero 插件