Harrison J E
Department of Cinical Dental Services, Liverpool University Dental Hospital and School of Dentistry, UK.
J Orthod. 2003 Mar;30(1):25-30; discussion 21. doi: 10.1093/ortho/30.1.25.
To test the hypothesis that there is insufficient evidence available, from clinical trials, to allow evidence-based decisions to be made on the effectiveness of orthodontic treatment.
To identify reports of orthodontic clinical trials and assess their demographic characteristics.
A retrospective, observational study.
The American Journal of Orthodontics and Dentofacial Orthopedics, British Journal of Orthodontics, and European Journal Orthodontics.
Clinical trials published between 1989 and 1998.
A hand-search was performed to identify all clinical trials. The journal and year of publication, research method, interventions, and sample size of the trials reported were recorded.
One-hundred-and-fifty-five trial reports were identified of which 56 (36.1%) were published from 1989 to 1993 and 99 (69%) from 1994 to 1998. Ninety-nine (69%) reports were published in the AJO-DO, 18 (11.6%) in the BJO and 38 (24.5%) in the EJO. Eighty-five (54.8%) were reports of randomized controlled trials and 70 (45.2%) of controlled clinical trials. The interventions most frequently assessed were bonding materials (21.9%), growth modification treatments (21.3%), and oral hygiene procedures (9.0%). The median sample size was 32 (IQR 19.5, 50).
There is sufficient evidence available from clinical trials to warrant doing systematic reviews of orthodontic clinical trials to aid decision-making.
检验如下假设，即从临床试验中获得的证据不足，无法基于证据对正畸治疗的有效性做出决策。
识别正畸临床试验报告并评估其人口统计学特征。
一项回顾性观察研究。
《美国正畸与牙颌面正畸杂志》《英国正畸杂志》和《欧洲正畸杂志》。
1989年至1998年发表的临床试验。
通过手工检索识别所有临床试验。记录所报告试验的期刊、发表年份、研究方法、干预措施和样本量。
共识别出155份试验报告，其中56份（36.1%）于1989年至1993年发表，99份（69%）于1994年至1998年发表。99份（69%）报告发表于《美国正畸与牙颌面正畸杂志》，18份（11.6%）发表于《英国正畸杂志》，38份（24.5%）发表于《欧洲正畸杂志》。85份（54.8%）为随机对照试验报告，70份（45.2%）为对照临床试验报告。最常评估的干预措施为粘结材料（21.9%）、生长改良治疗（21.3%）和口腔卫生措施（9.0%）。样本量中位数为32（四分位间距19.5，50）。
临床试验中有足够的证据支持对正畸临床试验进行系统评价以辅助决策。
