Doye Valérie
UMR 144 CNRS, Institut Curie, Section de Recherche, 26, rue d'Ulm, 75248 Paris.
J Soc Biol. 2002;196(4):349-54.
In eukaryotes, bidirectional transport of macro-molecules between the cytoplasm and the nucleus occurs through elaborate supramolecular structures embedded in the nuclear envelope, the nuclear pore complexes (NPCs), whose overall architecture has been evolutionary conserved from yeast to vertebrates. In recent years, fast progress in characterizing the NPCs components (the nucleoporins or Nups) has been made in the yeast S. cerevisiae, and to a lesser extent in vertebrates. In addition, despite the low homology between most yeast and vertebrate nucleoporins, their organization and their topological mapping within the NPC substructures have been broadly conserved during evolution.
在真核生物中，大分子在细胞质和细胞核之间的双向运输是通过嵌入核膜的精细超分子结构——核孔复合体（NPCs）进行的，其整体结构从酵母到脊椎动物在进化过程中一直保持保守。近年来，酿酒酵母在NPCs组分（核孔蛋白或Nups）的表征方面取得了快速进展，脊椎动物方面的进展则相对较小。此外，尽管大多数酵母和脊椎动物的核孔蛋白之间同源性较低，但它们在NPC亚结构中的组织方式和拓扑定位在进化过程中已基本保持保守。
