Jones Michael P, Shah Dhiren, Ebert Christine C
Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Dig Dis Sci. 2003 Jan;48(1):69-73. doi: 10.1023/a:1021782330906.
Proton pump inhibitors have been reported to delay gastric emptying, but this effect is controversial. Our aim was to determine the effect of rabeprazole sodium on several parameters of gastric function including gastric emptying, myoelectrical activity and ingested water volume required to produce fullness. Fifteen healthy males underwent assessment of solid-phase gastric emptying with the [13C] Spirulina platensis breath test as well as electrogastrography and satiety testing using a 5-min water load. Subjects were evaluated at baseline, after administration of placebo, and after rabeprazole sodium 20 mg daily for one week. No significant differences were seen between groups with respect to solid-phase gastric emptying as measured by T1/2 or T(lag). No differences were seen between baseline, placebo, and rabeprazole with respect to the number of normal electrogastrograms and the volume of water required to produce fullness. In conclusion, one week of therapy with rabeprazole sodium does not significantly alter gastric emptying, myoelectrical activity or threshold to fullness.
据报道，质子泵抑制剂会延迟胃排空，但这种作用存在争议。我们的目的是确定雷贝拉唑钠对胃功能的几个参数的影响，包括胃排空、肌电活动以及产生饱腹感所需的饮水量。15名健康男性接受了使用[13C]钝顶螺旋藻呼气试验评估固相胃排空，以及使用5分钟水负荷进行胃电图和饱腹感测试。在基线、服用安慰剂后以及每天服用20mg雷贝拉唑钠一周后对受试者进行评估。通过T1/2或T（延迟）测量的固相胃排空方面，各组之间未见显著差异。在正常胃电图数量和产生饱腹感所需的水量方面，基线、安慰剂和雷贝拉唑之间未见差异。总之，雷贝拉唑钠治疗一周不会显著改变胃排空、肌电活动或饱腹感阈值。
