Szeder Viktor, Grim Milos, Halata Zdenek, Sieber-Blum Maya
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Dev Biol. 2003 Jan 15;253(2):258-63. doi: 10.1016/s0012-1606(02)00015-5.
Here, we provide evidence for the neural crest origin of mammalian Merkel cells. Together with nerve terminals, Merkel cells form slowly adapting cutaneous mechanoreceptors that transduce steady indentation in hairy and glabrous skin. We have determined the ontogenetic origin of Merkel cells in Wnt1-cre/R26R compound transgenic mice, in which neural crest cells are marked indelibly. Merkel cells in whiskers and interfollicular locations express the transgene, beta-galactosidase, identifying them as neural crest descendants. We thus conclude that murine Merkel cells originate from the neural crest.
在此，我们提供了哺乳动物默克尔细胞起源于神经嵴的证据。默克尔细胞与神经末梢一起形成缓慢适应性皮肤机械感受器，可传导多毛和无毛皮肤中的持续压痕。我们已经确定了Wnt1-cre/R26R复合转基因小鼠中默克尔细胞的个体发生起源，其中神经嵴细胞被永久性标记。触须和毛囊间部位的默克尔细胞表达转基因β-半乳糖苷酶，将它们鉴定为神经嵴后代。因此，我们得出结论，小鼠默克尔细胞起源于神经嵴。
