Biswas Abhik K, Zabrocki Luke A, Mayes Kendra L, Morris-Kukoski Cynthia L
Pediatric Critical Care Medicine, Naval Medical Center Portsmouth, Portsmouth, Virginia 23708, USA.
J Toxicol Clin Toxicol. 2003;41(1):79-82. doi: 10.1081/clt-120018276.
Ziprasidone (Geodon) and bupropion (Wellbutrin) are medications prescribed for mood and behavior disorders. They have apparently safe cardiac safety profiles in both therapeutic and supra-therapeutic doses.
A 17-year-old male developed a widened QRS and a prolonged QTc interval following an overdose of ziprasidone and bupropion. He required hospital admission for aggressive cardiac monitoring and antidysrhythmic therapy, stabilizing to baseline by 80 hours post-ingestion.
We present a case that underscores the potential cardiotoxicities of these medications. Ziprasidone and bupropion ingestion can be associated with cardiotoxicities that may require several days of aggressive cardiac monitoring and treatment.
齐拉西酮（卓乐定）和安非他酮（安非他酮缓释片）是用于治疗情绪和行为障碍的药物。它们在治疗剂量和超治疗剂量下的心脏安全性概况显然是安全的。
一名17岁男性在过量服用齐拉西酮和安非他酮后出现QRS波增宽和QTc间期延长。他需要住院进行积极的心脏监测和抗心律失常治疗，摄入后80小时恢复到基线水平。
我们报告了一例强调这些药物潜在心脏毒性的病例。摄入齐拉西酮和安非他酮可能与心脏毒性有关，可能需要几天的积极心脏监测和治疗。
