Craigmill Arthur L, Cortright Kristy A
Food Animal Residue Avoidance Databank, Environmental Toxicology, University of California, One Shields Ave, Davis, CA 95616, USA.
AAPS PharmSci. 2002;4(4):E34. doi: 10.1208/ps040434.
Residues are composed of the parent drug and metabolites, and therefore interspecies comparisons must involve a consideration of comparative xenobiotic metabolism. The focus of this article will be the residue studies that are required to establish human food safety, and the interspecies pharmacokinetic differences and similarities that impact drug residues in animal- derived foods. To illustrate the factors that can complicate and assist these comparisons, 2 drugs will be examined in detail: ivermectin and fenbendazole. In addition, the activities of 2 US programs, the Food Animal Residue Avoidance Databank (FARAD) and the NRSP-7 (National Research Support Project Number 7) Minor Use Animal Drug Program will be presented, along with strategies that may be employed in the study of species differences.
残留物由母体药物和代谢物组成，因此种间比较必须考虑比较性的外源性物质代谢。本文的重点将是确定人类食品安全所需的残留研究，以及影响动物源性食品中药物残留的种间药代动力学差异和相似性。为了说明可能使这些比较复杂化和提供帮助的因素，将详细研究两种药物：伊维菌素和芬苯达唑。此外，还将介绍美国的两个项目——食用动物残留避免数据库（FARAD）和NRSP - 7（国家研究支持项目7号）小用量动物药物项目的活动，以及在物种差异研究中可能采用的策略。
